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Information Journal Paper

Title

SIMULTANEOUS OPTIMIZATION OF MULTIPLE RESPONSE VARIABLES FOR THE GELATIN- CHITOSAN MICROCAPSULES CONTAINING ANGELICA ESSENTIAL OIL

Pages

  50-62

Abstract

 Angelica essential oil (AO), a major pharmacologically active component of Angelica sinensis (Oliv.) Diels, possesses hemogenesis, analgesic activities, and sedative effect. The application of AO in pharmaceutical systems had been limited because of its low oxidative stability. The AO-loaded GELATIN- chitosan MICROCAPSULES with prevention from oxidation were developed and optimized using response surface methodology. The effects of formulation variables (pH at complex coacervation, GELATIN concentration, and core/wall ratio) on multiple response variables (yield, encapsulation efficiency, ANTIOXIDATION RATE, percent of drug released in 1 h, and time to 85% drug release) were systemically investigated. A desirability function that combined these five response variables was constructed. All response variables investigated were found to be highly dependent on the formulation variables, with strong interactions observed between the formulation variables. It was found that optimum overall desirability of AO MICROCAPSULES could be obtained at pH 6.20, GELATIN concentration 25.00%, and core/ wall ratio 40.40%. The experimental values of the response variables highly agreed with the predicted values. The ANTIOXIDATION RATE of optimum formulation was approximately 8 times higher than that of AO. The in-vitro drug release from MICROCAPSULES was followed Higuchi model with super case-II transport mechanism.

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    • Cite

    APA: Copy

    LI, QIANG, SUN, LI JIAN, GONG, XIAN FENG, WANG, YANG, & ZHAO, XUE LING. (2017). SIMULTANEOUS OPTIMIZATION OF MULTIPLE RESPONSE VARIABLES FOR THE GELATIN- CHITOSAN MICROCAPSULES CONTAINING ANGELICA ESSENTIAL OIL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 50-62. SID. https://sid.ir/paper/288810/en

    Vancouver: Copy

    LI QIANG, SUN LI JIAN, GONG XIAN FENG, WANG YANG, ZHAO XUE LING. SIMULTANEOUS OPTIMIZATION OF MULTIPLE RESPONSE VARIABLES FOR THE GELATIN- CHITOSAN MICROCAPSULES CONTAINING ANGELICA ESSENTIAL OIL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):50-62. Available from: https://sid.ir/paper/288810/en

    IEEE: Copy

    QIANG LI, LI JIAN SUN, XIAN FENG GONG, YANG WANG, and XUE LING ZHAO, “SIMULTANEOUS OPTIMIZATION OF MULTIPLE RESPONSE VARIABLES FOR THE GELATIN- CHITOSAN MICROCAPSULES CONTAINING ANGELICA ESSENTIAL OIL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 50–62, 2017, [Online]. Available: https://sid.ir/paper/288810/en

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