A SIMPLE AND SPECIFIC STABILITY- INDICATING RP-HPLC METHOD FOR ROUTINE ASSAY OF ADEFOVIR DIPIVOXIL IN BULK AND TABLET DOSAGE FORM

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DARSAZAN BAHAR; SHAFAATI ALIREZA; MORTAZAVI SEYED ALIREZA; ZARGHI AFSHIN

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:1 Page(s): 132-139

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Title

A SIMPLE AND SPECIFIC STABILITY- INDICATING RP-HPLC METHOD FOR ROUTINE ASSAY OF ADEFOVIR DIPIVOXIL IN BULK AND TABLET DOSAGE FORM

Author(s)

DARSAZAN BAHAR | SHAFAATI ALIREZA | MORTAZAVI SEYED ALIREZA | ZARGHI AFSHIN | Issue Writer Certificate

Keywords

ADEFOVIR DIPIVOXIL

ASSAY

RP-HPLC

STABILITY- INDICATING

PHARMACEUTICAL DOSAGE FORM

Abstract

A simple and reliable STABILITY- INDICATING RP-HPLC method was developed and validated for analysis of ADEFOVIR DIPIVOXIL (ADV).The chromatographic separation was performed on a C18 column using a mixture of acetonitrile-citrate buffer (10 mM at pH 5.2) 36: 64 (%v/v) as mobile phase, at a flow rate of 1.5 mL/min. Detection was carried out at 260 nm and a sharp peak was obtained for ADV at a retention time of 5.8±0.01 min. No interferences were observed from its stress degradation products. The method was validated according to the international guidelines. Linear regression analysis of data for the calibration plot showed a linear relationship between peak area and concentration over the range of 0.5–16 mg/mL; the regression coefficient was 0.9999and the linear regression equation was y=24844x-2941.3. The detection (LOD) and quantification (LOQ) limits were 0.12 and 0.35 mg/mL, respectively. The results proved the method was fast (analysis time less than 7 min), precise, reproducible, and accurate for analysis of ADV over a wide range of concentration. The proposed specific method was used for routine quantification of ADV in pharmaceutical bulk and a tablet dosage form.

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APA: Copy

DARSAZAN, BAHAR, SHAFAATI, ALIREZA, MORTAZAVI, SEYED ALIREZA, & ZARGHI, AFSHIN. (2017). A SIMPLE AND SPECIFIC STABILITY- INDICATING RP-HPLC METHOD FOR ROUTINE ASSAY OF ADEFOVIR DIPIVOXIL IN BULK AND TABLET DOSAGE FORM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 132-139. SID. https://sid.ir/paper/288812/en

Vancouver: Copy

DARSAZAN BAHAR, SHAFAATI ALIREZA, MORTAZAVI SEYED ALIREZA, ZARGHI AFSHIN. A SIMPLE AND SPECIFIC STABILITY- INDICATING RP-HPLC METHOD FOR ROUTINE ASSAY OF ADEFOVIR DIPIVOXIL IN BULK AND TABLET DOSAGE FORM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):132-139. Available from: https://sid.ir/paper/288812/en

IEEE: Copy

BAHAR DARSAZAN, ALIREZA SHAFAATI, SEYED ALIREZA MORTAZAVI, and AFSHIN ZARGHI, “A SIMPLE AND SPECIFIC STABILITY- INDICATING RP-HPLC METHOD FOR ROUTINE ASSAY OF ADEFOVIR DIPIVOXIL IN BULK AND TABLET DOSAGE FORM,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 132–139, 2017, [Online]. Available: https://sid.ir/paper/288812/en

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