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Information Journal Paper

Title

CYTOTOXIC PROPERTIES OF THREE ISOLATED COUMARIN- HEMITERPENE ETHER DERIVATIVES FROM ARTEMISIA ARMENIACA LAM

Pages

  221-229

Abstract

 Considering multiple reports on cytotoxic activity of the Artemisia genus and its phytochemicals, in the current study A. armeniaca Lam. and the three components isolated from the plant were subjected to cytotoxic studies. Analytical fractionation of A. armeniaca aerial parts for the first time was directed to the isolation of 7-hydroxy-8- (4-hydroxy-3-methylbutoxy) comarin (armenin), 8-hydroxy-7- (4-hydroxy-3-methylbutoxy) comarin (isoarmenin) and deoxylacarol. Cytotoxicity assessed with alamalBlueÒ assay and APOPTOSIS was detected by PI staining and western blot analysis of Bax and PARP proteins. Extracts and all compounds exhibited cytotoxic activity against APOPTOSIS- proficient HL-60 and APOPTOSIS- resistant K562 cells, with the lowest cytotoxic activity on J774 cell line as non-malignant cell.Armenin as the most potent component decreased the viability of cell with IC50 of 22.5 and 71.1 mM for K562 and HL-60 cells respectively and selected for further mechanistic study. Armenin increased the sub-G1 peak in flow cytometry histogram of HL-60 and K562 treatedcells and increase in the amount of Bax protein and the cleavage of PARP in comparison with the control after treatment for 48 h in K562 treated cells verified the apoptotic activity of the armenin.Taken together, according to the finding of this study armenin was introduced as a novelcytotoxic compound with apoptotic activity, which is encouraging for further mechanistic and clinical studies.

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    APA: Copy

    MOJARRAB, MAHDI, EMAMI, SEYED AHMAD, DELAZAR, ABBAS, & TAYARANI NAJARAN, ZAHRA. (2017). CYTOTOXIC PROPERTIES OF THREE ISOLATED COUMARIN- HEMITERPENE ETHER DERIVATIVES FROM ARTEMISIA ARMENIACA LAM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 221-229. SID. https://sid.ir/paper/288813/en

    Vancouver: Copy

    MOJARRAB MAHDI, EMAMI SEYED AHMAD, DELAZAR ABBAS, TAYARANI NAJARAN ZAHRA. CYTOTOXIC PROPERTIES OF THREE ISOLATED COUMARIN- HEMITERPENE ETHER DERIVATIVES FROM ARTEMISIA ARMENIACA LAM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):221-229. Available from: https://sid.ir/paper/288813/en

    IEEE: Copy

    MAHDI MOJARRAB, SEYED AHMAD EMAMI, ABBAS DELAZAR, and ZAHRA TAYARANI NAJARAN, “CYTOTOXIC PROPERTIES OF THREE ISOLATED COUMARIN- HEMITERPENE ETHER DERIVATIVES FROM ARTEMISIA ARMENIACA LAM,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 221–229, 2017, [Online]. Available: https://sid.ir/paper/288813/en

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