ANTIBACTERIAL LOADED SPRAY DRIED CHITOSAN POLYELECTROLYTE COMPLEXES AS DRY POWDER AEROSOL FOR THE TREATMENT OF LUNG INFECTIONS

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MISHRA BRAHMESHWAR; MISHRA MADHUSMITA; YADAV SARITA KUMARI

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:1 Page(s): 74-92

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Title

ANTIBACTERIAL LOADED SPRAY DRIED CHITOSAN POLYELECTROLYTE COMPLEXES AS DRY POWDER AEROSOL FOR THE TREATMENT OF LUNG INFECTIONS

Author(s)

MISHRA BRAHMESHWAR | MISHRA MADHUSMITA | YADAV SARITA KUMARI | Issue Writer Certificate

Keywords

LEVOFLOXACIN

DOXYCYCLINE

INHALER

AEROSOL

SPRAY DRIED

Abstract

Inhalation delivery of AEROSOLized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, SPRAY DRIED, AEROSOLized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections.Chitosan polyelectrolyte complex micro particles were formulated by spray drying process. Prepared SPRAY DRIED chitosan PEC micro particles were studied for surface morphology, drug encapsulation efficiency, moisture content, Carr’s index, solid state interaction by XRD, AEROSOLization behaviour and in-vitro drug release. In-vitro cytotoxicity studies of micro particles were carried out on H1299 alveolar cell lines. Antibacterial efficacy of micro particles was assessed on the basis of determination of pharmacokinetic parameters in bronchial alveolar lavage (BAL) of rats using PK/PD analysis.The PEC micro particles were mostly spherical and exhibited high drug encapsulation efficiency. Release profiles showed an initial burst phase followed by a secondary sustained release phase. Good AEROSOLization behaviour as dry powder INHALER was demonstrated by micro particles with high values of recovered dose, emitted dose, and fine particle fraction. No overt cytotoxicity of micro particles was detected against H1299 alveolar cell line. More than 8 to 9 folds higher Cmax values were obtained in BAL fluid with micro particles as compared to intravenously administered antibacterial solution.The findings of the study suggest that chitosan polyelectrolyte complex based micro particles as dry powder INHALER can be an efficient antibacterial delivery system for sustained and effective management of lung infection.

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APA: Copy

MISHRA, BRAHMESHWAR, MISHRA, MADHUSMITA, & YADAV, SARITA KUMARI. (2017). ANTIBACTERIAL LOADED SPRAY DRIED CHITOSAN POLYELECTROLYTE COMPLEXES AS DRY POWDER AEROSOL FOR THE TREATMENT OF LUNG INFECTIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 74-92. SID. https://sid.ir/paper/288829/en

Vancouver: Copy

MISHRA BRAHMESHWAR, MISHRA MADHUSMITA, YADAV SARITA KUMARI. ANTIBACTERIAL LOADED SPRAY DRIED CHITOSAN POLYELECTROLYTE COMPLEXES AS DRY POWDER AEROSOL FOR THE TREATMENT OF LUNG INFECTIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):74-92. Available from: https://sid.ir/paper/288829/en

IEEE: Copy

BRAHMESHWAR MISHRA, MADHUSMITA MISHRA, and SARITA KUMARI YADAV, “ANTIBACTERIAL LOADED SPRAY DRIED CHITOSAN POLYELECTROLYTE COMPLEXES AS DRY POWDER AEROSOL FOR THE TREATMENT OF LUNG INFECTIONS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 74–92, 2017, [Online]. Available: https://sid.ir/paper/288829/en

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