INTERFERENCE- FREE DETERMINATION OF CARBAMAZEPINE IN HUMAN SERUM USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY: A COMPREHENSIVE RESEARCH WITH THREE- WAY CALIBRATION METHODS

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Ghafghazi Shiva; MOINI ZANJANI TARANEH; VOSOUGH MARYAM; SABETKASAEI MASOUMEH

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:1 Page(s): 120-131

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Title

INTERFERENCE- FREE DETERMINATION OF CARBAMAZEPINE IN HUMAN SERUM USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY: A COMPREHENSIVE RESEARCH WITH THREE- WAY CALIBRATION METHODS

Author(s)

Ghafghazi Shiva | MOINI ZANJANI TARANEH | VOSOUGH MARYAM | SABETKASAEI MASOUMEH | Issue Writer Certificate

Keywords

CARBAMAZEPINE

HIGH- PERFORMANCE LIQUID CHROMATOGRAPHY

MULTI- WAY ALGORITHMS

SERUM

Abstract

In the present study, a comprehensive and systematic strategy was described to evaluate the performance of several three- way calibration methods on a bio- analytical problem. Parallel factor analysis (PARAFAC), alternating trilinear decomposition (ATLD), self- weighted alternating trilinear decomposition (SWATLD), alternating penalty trilinear decomposition (APTLD), and unfolded partial least squares combined with the residual bilinearization procedure (U-PLS/RBL) were applied on high performance liquid chromatography with photodiode-array detection (HPLC-DAD) data to quantify CARBAMAZEPINE (CBZ) in different SERUM samples. Using the proposed approach, successfully quantification of CBZ in human plasma, even in the presence of diverse uncalibrated serious interfering components was achieved. Moreover, the accuracy and precision of each algorithm for analyzing CBZ in SERUM samples were compared using root mean square error of prediction (RMSEP), the recovery values and figures of merits and reproducibility of the analysis. Satisfying recovery values for the analyte of interest were obtained by HPLC-DAD on a Bonus-RP column using an isocratic mode of elution with acetonitrile/K2HPO4 (pH=7.5) buffer solution (45: 55) coupled with second- order calibrations. Decreas of the analysis time and less solvent consumption are some of the pluses of this method. The analysis of real samples showed that the modeling of complex chromatographic profiles containing CBZ as the target drug using any of the mentioned algorithms can be potentially benefit drug monitoring in therapeutic research.

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APA: Copy

Ghafghazi, Shiva, MOINI ZANJANI, TARANEH, VOSOUGH, MARYAM, & SABETKASAEI, MASOUMEH. (2017). INTERFERENCE- FREE DETERMINATION OF CARBAMAZEPINE IN HUMAN SERUM USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY: A COMPREHENSIVE RESEARCH WITH THREE- WAY CALIBRATION METHODS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 120-131. SID. https://sid.ir/paper/288835/en

Vancouver: Copy

Ghafghazi Shiva, MOINI ZANJANI TARANEH, VOSOUGH MARYAM, SABETKASAEI MASOUMEH. INTERFERENCE- FREE DETERMINATION OF CARBAMAZEPINE IN HUMAN SERUM USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY: A COMPREHENSIVE RESEARCH WITH THREE- WAY CALIBRATION METHODS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):120-131. Available from: https://sid.ir/paper/288835/en

IEEE: Copy

Shiva Ghafghazi, TARANEH MOINI ZANJANI, MARYAM VOSOUGH, and MASOUMEH SABETKASAEI, “INTERFERENCE- FREE DETERMINATION OF CARBAMAZEPINE IN HUMAN SERUM USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY: A COMPREHENSIVE RESEARCH WITH THREE- WAY CALIBRATION METHODS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 120–131, 2017, [Online]. Available: https://sid.ir/paper/288835/en

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