SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(5-(PYRIDIN-2-YL)-1,3,4-THIADIAZOL- 2-YL)BENZAMIDE DERIVATIVES AS LIPOXYGENASE INHIBITOR WITH POTENTIAL ANTICANCER ACTIVITY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ALIABADI ALIREZA; MOHAMMADI FARANI AHMAD; ROODABEH SAHAR; AHMADI FARAHNAZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:1 Page(s): 165-172

Download Full-Text

View:

301

Download:

123

Cites:

Information Journal Paper

Title

SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(5-(PYRIDIN-2-YL)-1,3,4-THIADIAZOL- 2-YL)BENZAMIDE DERIVATIVES AS LIPOXYGENASE INHIBITOR WITH POTENTIAL ANTICANCER ACTIVITY

Author(s)

ALIABADI ALIREZA | MOHAMMADI FARANI AHMAD | ROODABEH SAHAR | AHMADI FARAHNAZ | Issue Writer Certificate

Keywords

PYRIDINE

4-THIADIAZOLE

SYNTHESIS

LIPOXYGENASE

MTT

Abstract

In the recent years, the role of LOX enzymes in the origin of neoplastic diseases such as colorectal, skin, pancreatic and renal cancers has been confirmed. A new series of 1, 3, 4-THIADIAZOLE derivatives bearing 2-pyridyl moiety was synthesized and the cytotoxicity of the members of this series was assessed using MTT protocol. Enzyme inhibitory activity of the prepared compounds was also tested against 15-lipoxygenase-1 as a novel target for the discovery of anticancer drugs. PC3, HT29 and SKNMC cell lines were utilized and the obtained results were compared with doxorubicin. Overall, nitro containing derivatives exerted a higher cytotoxic activity against PC3 cell line and methoxylated derivatives showed an acceptable activity against SKNMC cell line. Methoxylated derivatives were also the most potent enzyme inhibitors especially at position ortho of the phenyl residue.

Cites

Design, synthesis, molecular docking study and biological evaluation of heteroaryl 2-phenoxypyridin-3-yl derivatives as lipoxygenase enzyme inhibitors

References

No record.

Cite

APA: Copy

ALIABADI, ALIREZA, MOHAMMADI FARANI, AHMAD, ROODABEH, SAHAR, & AHMADI, FARAHNAZ. (2017). SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(5-(PYRIDIN-2-YL)-1,3,4-THIADIAZOL- 2-YL)BENZAMIDE DERIVATIVES AS LIPOXYGENASE INHIBITOR WITH POTENTIAL ANTICANCER ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 165-172. SID. https://sid.ir/paper/288838/en

Vancouver: Copy

ALIABADI ALIREZA, MOHAMMADI FARANI AHMAD, ROODABEH SAHAR, AHMADI FARAHNAZ. SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(5-(PYRIDIN-2-YL)-1,3,4-THIADIAZOL- 2-YL)BENZAMIDE DERIVATIVES AS LIPOXYGENASE INHIBITOR WITH POTENTIAL ANTICANCER ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):165-172. Available from: https://sid.ir/paper/288838/en

IEEE: Copy

ALIREZA ALIABADI, AHMAD MOHAMMADI FARANI, SAHAR ROODABEH, and FARAHNAZ AHMADI, “SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(5-(PYRIDIN-2-YL)-1,3,4-THIADIAZOL- 2-YL)BENZAMIDE DERIVATIVES AS LIPOXYGENASE INHIBITOR WITH POTENTIAL ANTICANCER ACTIVITY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 165–172, 2017, [Online]. Available: https://sid.ir/paper/288838/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops