PHENETHYL ISOTHIOCYANATE TRIGGERS APOPTOSIS, COMBATS OXIDATIVE STRESS AND INHIBITS GROWTH OF EHRLICH ASCITES CARCINOMA MOUSE MODEL

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EISA NADA H.; SAID HEBA S.; ELSHERBINY NEHAL M.; EISSA LAILA A.; EL SHISHTAWY MAMDOUH M.

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:4 Page(s): 1328-1338

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Title

PHENETHYL ISOTHIOCYANATE TRIGGERS APOPTOSIS, COMBATS OXIDATIVE STRESS AND INHIBITS GROWTH OF EHRLICH ASCITES CARCINOMA MOUSE MODEL

Author(s)

Keywords

APOPTOSIS

BAX

BCL-2

CASPASE-9

EHRLICH ASCITES CARCINOMA

PHENETHYL ISOTHIOCYANATE

Abstract

The aim of this study is to investigate the antitumor activity and possible molecular mechanism of PHENETHYL ISOTHIOCYANATE (PEITC) against EHRLICH ASCITES CARCINOMA in-vivo and in-vitro. In-vivo, ascetic fluid volume, body weight, serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were determined using EHRLICH ASCITES CARCINOMA (EAC) bearing mice. In-vitro, MTT assay was used. RT-PCR was used to investigate role of PEITC in APOPTOSIS by analyzing the expression of BAX, CASPASE-9, and BCL-2 genes. The effect of PEITC on CASPASE-9 enzyme activity was also tested. PEITC and/or Doxorubicin (Dox) treatment significantly suppressed EAC growth as compared to EAC/oil control mice. PEITC treatment showed a dose-dependent inhibition of EAC cells as indicated by MTT assay. We found that significant increase in MDA level and decrease in TAC caused by Dox treatment were significantly reduced by combination with PEITC treatment. BAX, CASPASE-9 genes’ expression and CASPASE-9 enzymatic activity were significantly increased, while BCL-2 gene expression was significantly decreased in PEITC treated mice. PEITC may act as a promising anticancer agent either alone or more effectively in combination with Dox through apoptotic cell death induction.

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APA: Copy

EISA, NADA H., SAID, HEBA S., ELSHERBINY, NEHAL M., EISSA, LAILA A., & EL SHISHTAWY, MAMDOUH M.. (2018). PHENETHYL ISOTHIOCYANATE TRIGGERS APOPTOSIS, COMBATS OXIDATIVE STRESS AND INHIBITS GROWTH OF EHRLICH ASCITES CARCINOMA MOUSE MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1328-1338. SID. https://sid.ir/paper/288894/en

Vancouver: Copy

EISA NADA H., SAID HEBA S., ELSHERBINY NEHAL M., EISSA LAILA A., EL SHISHTAWY MAMDOUH M.. PHENETHYL ISOTHIOCYANATE TRIGGERS APOPTOSIS, COMBATS OXIDATIVE STRESS AND INHIBITS GROWTH OF EHRLICH ASCITES CARCINOMA MOUSE MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1328-1338. Available from: https://sid.ir/paper/288894/en

IEEE: Copy

NADA H. EISA, HEBA S. SAID, NEHAL M. ELSHERBINY, LAILA A. EISSA, and MAMDOUH M. EL SHISHTAWY, “PHENETHYL ISOTHIOCYANATE TRIGGERS APOPTOSIS, COMBATS OXIDATIVE STRESS AND INHIBITS GROWTH OF EHRLICH ASCITES CARCINOMA MOUSE MODEL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1328–1338, 2018, [Online]. Available: https://sid.ir/paper/288894/en

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