DEVELOPMENT OF A NEW METHOD BASED ON CHIRAL LIGAND-EXCHANGE CHROMATOGRAPHY FOR THE ENANTIOSEPARATION OF PROPRANOLOL

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ALIZADEH TAHER

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1037-1047

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Title

DEVELOPMENT OF A NEW METHOD BASED ON CHIRAL LIGAND-EXCHANGE CHROMATOGRAPHY FOR THE ENANTIOSEPARATION OF PROPRANOLOL

Author(s)

ALIZADEH TAHER | Issue Writer Certificate

Keywords

ALANINE;CHIRAL SEPARATION;PROPRANOLOL;C8 COLUMN;LIGAND EXCHANGE

Abstract

A new chromatographic procedure was proposed for the separation of propranolol (PRN)enantiomers based upon enantioselective chiral ligand-exchange chromatography. Theseparation was carried out on a short C8 column leading to considerably short separationtime. L-alanine and Cu2+ were applied as chiral selector and central bivalent complexing ion, respectively. It was found that the kind of copper salt could influence the enantioseparationefficiency. The separation on the C8 stationary phase was more efficient than that on theC18 column. It was shown that the pH of mobile phase, organic modifier content of mobilephase, mole ratio of chiral ligand to bivalent ion and Cu (L-alanine) 2 concentration in themobile phase were important in enantioseparation efficiency. Water/methanol (70: 30) mixturecontaining L-alanine-Cu2+ (7: 1) was found to be the best mobile phase condition for PRNenantioseparation. All effective parameters were optimized in order to improve the separationefficiency. The optimized HPLC method was utilized for analysis of propranolol enantiomersin spiked human blood plasma samples.

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APA: Copy

ALIZADEH, TAHER. (2017). DEVELOPMENT OF A NEW METHOD BASED ON CHIRAL LIGAND-EXCHANGE CHROMATOGRAPHY FOR THE ENANTIOSEPARATION OF PROPRANOLOL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1037-1047. SID. https://sid.ir/paper/288969/en

Vancouver: Copy

ALIZADEH TAHER. DEVELOPMENT OF A NEW METHOD BASED ON CHIRAL LIGAND-EXCHANGE CHROMATOGRAPHY FOR THE ENANTIOSEPARATION OF PROPRANOLOL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1037-1047. Available from: https://sid.ir/paper/288969/en

IEEE: Copy

TAHER ALIZADEH, “DEVELOPMENT OF A NEW METHOD BASED ON CHIRAL LIGAND-EXCHANGE CHROMATOGRAPHY FOR THE ENANTIOSEPARATION OF PROPRANOLOL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1037–1047, 2017, [Online]. Available: https://sid.ir/paper/288969/en

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