ASSOCIATION OF WARFARIN THERAPY WITH APOE AND VKORC1 GENESPOLYMORPHISM IN IRANIAN POPULATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAFIEE SAJAD; RAJABIBAZL MASOUMEH; MESHKANI REZA; DARAEI AZAM; ZARGARI MEHRYAR; SHARAFEDDIN FAHIMEH; FAZELI ZAHRA; Toofani Milani Attabak; TAHERKHANI MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1230-1237

Download Full-Text

View:

245

Download:

Cites:

Information Journal Paper

Title

ASSOCIATION OF WARFARIN THERAPY WITH APOE AND VKORC1 GENESPOLYMORPHISM IN IRANIAN POPULATION

Author(s)

Keywords

WARFARIN THERAPY

APOE POLYMORPHISMS

VKORC1

IRANIAN POPULATION

CARDIOVASCULAR DISEASE

Abstract

Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (rs9923231) and the APOE (rs429358 and rs7412)polymorphisms were genotyped by PCR-RFLP technique. We found that the Iranian patientscarrying genotypes GA or AA of VKORC1 polymorphism tended to receive lower dose ofwarfarin (p = 0. 018). Furthermore, the E3/E3 genotype was observed with the frequency morethan 60% in the patients with low dose of warfarin. The BMI and weight also showed a positivecorrelation with warfarin dose. However, it was not statistically significant (p > 0. 05). Theresults of this study may be useful in defining of warfarin dose algorithms for Iranian patients.

Cites

No record.

References

No record.

Cite

APA: Copy

RAFIEE, SAJAD, RAJABIBAZL, MASOUMEH, MESHKANI, REZA, DARAEI, AZAM, ZARGARI, MEHRYAR, SHARAFEDDIN, FAHIMEH, FAZELI, ZAHRA, Toofani Milani, Attabak, & TAHERKHANI, MARYAM. (2017). ASSOCIATION OF WARFARIN THERAPY WITH APOE AND VKORC1 GENESPOLYMORPHISM IN IRANIAN POPULATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1230-1237. SID. https://sid.ir/paper/288976/en

Vancouver: Copy

RAFIEE SAJAD, RAJABIBAZL MASOUMEH, MESHKANI REZA, DARAEI AZAM, ZARGARI MEHRYAR, SHARAFEDDIN FAHIMEH, FAZELI ZAHRA, Toofani Milani Attabak, TAHERKHANI MARYAM. ASSOCIATION OF WARFARIN THERAPY WITH APOE AND VKORC1 GENESPOLYMORPHISM IN IRANIAN POPULATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1230-1237. Available from: https://sid.ir/paper/288976/en

IEEE: Copy

SAJAD RAFIEE, MASOUMEH RAJABIBAZL, REZA MESHKANI, AZAM DARAEI, MEHRYAR ZARGARI, FAHIMEH SHARAFEDDIN, ZAHRA FAZELI, Attabak Toofani Milani, and MARYAM TAHERKHANI, “ASSOCIATION OF WARFARIN THERAPY WITH APOE AND VKORC1 GENESPOLYMORPHISM IN IRANIAN POPULATION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1230–1237, 2017, [Online]. Available: https://sid.ir/paper/288976/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops