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Information Journal Paper

Title

FORMULATION DEVELOPMENT AND EVALUATION OF THE THERAPEUTIC EFFICACY OFBRINZOLAMIDE CONTAINING NANOEMULSIONS

Pages

  847-857

Abstract

 BRINZOLAMIDE (BZ) is an intraocular pressure reducing agent with low bioavailability. Thepurpose of the present study was to overcome this issue by development of BZ containingNANOEMULSIONs (NEs) as an OCULAR DRUG DELIVERY system with desirable THERAPEUTIC EFFICACY. BRINZOLAMIDE NEs were prepared by the spontaneous emulsification method. Based on initialrelease studies, twelve formulations with the slowest release characteristics were subjected tofurther physicochemical investigations such as particle size, polydispersity index, pH, refractiveindex, osmolality and viscosity. The THERAPEUTIC EFFICACY of these formulations was assessed bymeasuring the intraocular pressure after instillation of the prepared NEs in normotensive albinorabbit eyes. NANOEMULSIONs with suitable physicochemical properties exhibited high formulationstability under different conditions. more over biological evaluations indicated that using lowerdrug concentrations in NE formulations (0. 4%) had a similar or even better pharmacodynamiceffect compared to the commercial suspension with a higher drug concentration (1%). Ourfindings suggest that NEs could be effectively used as carriers for enhancing the bioavailabilityof topically applied ophthalmic drugs.

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    APA: Copy

    MAHBOOBIAN, MOHAMMAD MEHDI, SEYFODDIN, ALI, RUPENTHAL, ILVA D., ABOOFAZELI, REZA, & FOROUTAN, SEYED MOHSEN. (2017). FORMULATION DEVELOPMENT AND EVALUATION OF THE THERAPEUTIC EFFICACY OFBRINZOLAMIDE CONTAINING NANOEMULSIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 847-857. SID. https://sid.ir/paper/288978/en

    Vancouver: Copy

    MAHBOOBIAN MOHAMMAD MEHDI, SEYFODDIN ALI, RUPENTHAL ILVA D., ABOOFAZELI REZA, FOROUTAN SEYED MOHSEN. FORMULATION DEVELOPMENT AND EVALUATION OF THE THERAPEUTIC EFFICACY OFBRINZOLAMIDE CONTAINING NANOEMULSIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):847-857. Available from: https://sid.ir/paper/288978/en

    IEEE: Copy

    MOHAMMAD MEHDI MAHBOOBIAN, ALI SEYFODDIN, ILVA D. RUPENTHAL, REZA ABOOFAZELI, and SEYED MOHSEN FOROUTAN, “FORMULATION DEVELOPMENT AND EVALUATION OF THE THERAPEUTIC EFFICACY OFBRINZOLAMIDE CONTAINING NANOEMULSIONS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 847–857, 2017, [Online]. Available: https://sid.ir/paper/288978/en

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