EFFECT OF VITAMIN D SUPPLEMENTATION ON PROCALCITONIN AS PROGNOSTIC BIOMARKER IN PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA COMPLICATED WITH VITAMIN D DEFICIENCY

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MIROLIAEE AMIR EBRAHIM; SALAMZADEH JAMSHID; SHOKOUHI SHERVIN; FATEMI ALIREZA; ARDEHALI SEYED HOSSEIN; HAJIESMAEILI MOHAMMAD REZA; SAHRAEI ZAHRA

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1258-1267

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Title

EFFECT OF VITAMIN D SUPPLEMENTATION ON PROCALCITONIN AS PROGNOSTIC BIOMARKER IN PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA COMPLICATED WITH VITAMIN D DEFICIENCY

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Keywords

PROCALCITONIN

VAP

CPIS SCORE

SOFA SCORE

VITAMIN D

Abstract

Ventilator-associated pneumonia (VAP) is a common and serious problem that developsafter more than 48 h of mechanical ventilation. Improving the activity of immune system withVITAMIN D, and its consequent impact on prognostic biomarkers of VAP was studied in thecurrent study. A randomized double blind placebo controlled clinical trial was designed. A total of 46patients with VAP, who were suffering from VITAMIN D deficiency, were randomly allocatedinto the study groups of placebo (n=22) and treatment (n=24) The treatment group received300, 000 units of intramuscular VITAMIN D. Serum levels of PROCALCITONIN and VITAMIN D alongwith SOFA and CPIS SCOREs were determined at baseline and on day 7 after intervention. Themortality rate of patients was also monitored for the succeeding 28 days after the injection. The administration of VITAMIN D significantly enhanced its levels (P<0. 0001) in the treatedpatients (12. 28 ± 8. 26) in comparison to placebo group (1. 15 ± 1. 50). The levels of PCT weresignificantly decreased (p=0. 001) in the treatment group (– 0. 02 ± 0. 59 ng/mL) compared to thatof placebo group (0. 68 ± 1. 03 ng/mL). However, changes in (SOFA) and CPIS SCOREs were notsignificantly different between study groups (p=0. 63 and p=0. 32, respectively). Interestingly, the mortality rate of patients in the treatment group (5/24) was significantly lower (p=0. 04) thanthat of the placebo group (11/22). In conclusion, our results indicate that VITAMIN D supplementation can significantly reducethe PROCALCITONIN in (VAP) patients, and must be considered as a preventive and/or therapeuticstrategy.

Cites

The effects of selenium supplementation on clinical outcomes in mechanically ventilated, non-surgical/traumatic critically ill patients

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APA: Copy

MIROLIAEE, AMIR EBRAHIM, SALAMZADEH, JAMSHID, SHOKOUHI, SHERVIN, FATEMI, ALIREZA, ARDEHALI, SEYED HOSSEIN, HAJIESMAEILI, MOHAMMAD REZA, & SAHRAEI, ZAHRA. (2017). EFFECT OF VITAMIN D SUPPLEMENTATION ON PROCALCITONIN AS PROGNOSTIC BIOMARKER IN PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA COMPLICATED WITH VITAMIN D DEFICIENCY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1258-1267. SID. https://sid.ir/paper/288986/en

Vancouver: Copy

MIROLIAEE AMIR EBRAHIM, SALAMZADEH JAMSHID, SHOKOUHI SHERVIN, FATEMI ALIREZA, ARDEHALI SEYED HOSSEIN, HAJIESMAEILI MOHAMMAD REZA, SAHRAEI ZAHRA. EFFECT OF VITAMIN D SUPPLEMENTATION ON PROCALCITONIN AS PROGNOSTIC BIOMARKER IN PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA COMPLICATED WITH VITAMIN D DEFICIENCY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1258-1267. Available from: https://sid.ir/paper/288986/en

IEEE: Copy

AMIR EBRAHIM MIROLIAEE, JAMSHID SALAMZADEH, SHERVIN SHOKOUHI, ALIREZA FATEMI, SEYED HOSSEIN ARDEHALI, MOHAMMAD REZA HAJIESMAEILI, and ZAHRA SAHRAEI, “EFFECT OF VITAMIN D SUPPLEMENTATION ON PROCALCITONIN AS PROGNOSTIC BIOMARKER IN PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA COMPLICATED WITH VITAMIN D DEFICIENCY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1258–1267, 2017, [Online]. Available: https://sid.ir/paper/288986/en

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