ESTERS OF QUINOXALINE 1ˏ 4-DI-N-OXIDE WITH CYTOTOXIC ACTIVITY ON TUMORCELL LINES BASED ON NCI-60 PANEL

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RIVERA GILDARDO; SYED SHOAIB AHMAD SHAH; ARRIETA BAEZ DANIEL; PALOS ISIDRO; MONGUE ANTONIO; SANCHEZ TORRES LUVIA ENID

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 953-965

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Title

ESTERS OF QUINOXALINE 1ˏ 4-DI-N-OXIDE WITH CYTOTOXIC ACTIVITY ON TUMORCELL LINES BASED ON NCI-60 PANEL

Author(s)

Keywords

ANTITUMOR

CANCER

DRUGS

ESTERS

QUINOXALINE 1

4-DI-N-OXIDE

Abstract

Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and antiCANCER agents. Particularly, their 1ˏ 4-DI-N-OXIDE derivatives haveproved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of QUINOXALINE 1ˏ 4-DI-N-OXIDE substitutes at 7-position with ESTERS group weresynthetized and characterized by infrared (IR), proton nuclear magnetic resonance (1H-NMR), spectroscopy, and elemental analysis. Seventeen derivatives (M1-M3, E1-E8, P1-P3 and DR1-DR3) were selected and evaluated for ANTITUMOR activities using the NCI-60 human tumor celllines screen. Results showed that E7, P3 and E6 were the most active compounds againstthe cell lines tested. Substitutions at 7-position with ESTERS group not necessarily affect thebiological activity, but the nature of the ESTERS group could exert an influence on the selectivity. Additionally, substitutions at 2-position influenced the cytotoxic activity of the compounds.

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APA: Copy

RIVERA, GILDARDO, SYED SHOAIB, AHMAD SHAH, ARRIETA BAEZ, DANIEL, PALOS, ISIDRO, MONGUE, ANTONIO, & SANCHEZ TORRES, LUVIA ENID. (2017). ESTERS OF QUINOXALINE 1? 4-DI-N-OXIDE WITH CYTOTOXIC ACTIVITY ON TUMORCELL LINES BASED ON NCI-60 PANEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 953-965. SID. https://sid.ir/paper/288988/en

Vancouver: Copy

RIVERA GILDARDO, SYED SHOAIB AHMAD SHAH, ARRIETA BAEZ DANIEL, PALOS ISIDRO, MONGUE ANTONIO, SANCHEZ TORRES LUVIA ENID. ESTERS OF QUINOXALINE 1? 4-DI-N-OXIDE WITH CYTOTOXIC ACTIVITY ON TUMORCELL LINES BASED ON NCI-60 PANEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):953-965. Available from: https://sid.ir/paper/288988/en

IEEE: Copy

GILDARDO RIVERA, AHMAD SHAH SYED SHOAIB, DANIEL ARRIETA BAEZ, ISIDRO PALOS, ANTONIO MONGUE, and LUVIA ENID SANCHEZ TORRES, “ESTERS OF QUINOXALINE 1? 4-DI-N-OXIDE WITH CYTOTOXIC ACTIVITY ON TUMORCELL LINES BASED ON NCI-60 PANEL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 953–965, 2017, [Online]. Available: https://sid.ir/paper/288988/en

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