EXPRESSION OF TOLC AND ORGANIC SOLVENT TOLERANCE OF ESCHERICHIA COLICIPROFLOXACIN RESISTANT MUTANTS

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POURAHMAD JAKTAJI RAZIEH; ZARGAMPOOR FARZANEH

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1185-1189

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Information Journal Paper

Title

EXPRESSION OF TOLC AND ORGANIC SOLVENT TOLERANCE OF ESCHERICHIA COLICIPROFLOXACIN RESISTANT MUTANTS

Author(s)

POURAHMAD JAKTAJI RAZIEH | ZARGAMPOOR FARZANEH | Issue Writer Certificate

Keywords

ACRAB

TOLC EFFLUX PUMP;CIPROFLOXACIN;E.COLI;ORGANIC SOLVENT TOLERANCE;TOLC;MARR.

Abstract

ACRAB-TolC is a major efflux pump in Escherichia coli. It was reported that tolC is overexpressed andinvolves in improving the organic solvent tolerance level in Escherichia coli marR mutants that are resistantto several antibiotics, such as ciprofloxacin. Low and intermediate levels resistance did not improve organicsolvent tolerance. Thus, it was decided to measure tolC expression and organic solvent tolerance in high levelciprofloxacin resistant mutants. tolC expression was measured by real time PCR and organic solvent toleranceassay was conducted by counting bacterial colonies on LBGMg agar. Results showed that tolC expression wasincreased significantly (P<0. 05) and organic solvent tolerance was slightly improved in high resistant mutants. It was concluded that high organic solvent tolerance may need higher expression of tolC.

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APA: Copy

POURAHMAD JAKTAJI, RAZIEH, & ZARGAMPOOR, FARZANEH. (2017). EXPRESSION OF TOLC AND ORGANIC SOLVENT TOLERANCE OF ESCHERICHIA COLICIPROFLOXACIN RESISTANT MUTANTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1185-1189. SID. https://sid.ir/paper/288991/en

Vancouver: Copy

POURAHMAD JAKTAJI RAZIEH, ZARGAMPOOR FARZANEH. EXPRESSION OF TOLC AND ORGANIC SOLVENT TOLERANCE OF ESCHERICHIA COLICIPROFLOXACIN RESISTANT MUTANTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1185-1189. Available from: https://sid.ir/paper/288991/en

IEEE: Copy

RAZIEH POURAHMAD JAKTAJI, and FARZANEH ZARGAMPOOR, “EXPRESSION OF TOLC AND ORGANIC SOLVENT TOLERANCE OF ESCHERICHIA COLICIPROFLOXACIN RESISTANT MUTANTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1185–1189, 2017, [Online]. Available: https://sid.ir/paper/288991/en

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