ANTICONVULSANT EFFECTS OF NEW 1, 4-DIHYDROPYRIDINEDERIVATIVESCONTAINING IMIDAZOLYL MOIETY AGAINST SEIZURES INDUCED BYPENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK IN MICE

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RASOULI YASAMAN; DAVOOD ASGHAR; ALAEE ARMIN; DEHQANI GOLNOUSH; SHAFAROUDI HAMED; LOTFINIA MAHBOUBEH; AMINI MOHSEN; SHAFIEE ABBAS

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 893-903

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Title

ANTICONVULSANT EFFECTS OF NEW 1, 4-DIHYDROPYRIDINEDERIVATIVESCONTAINING IMIDAZOLYL MOIETY AGAINST SEIZURES INDUCED BYPENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK IN MICE

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Keywords

DIHYDROPYRIDINE;IMIDAZOLE;ANTICONVULSANT;PENTYLENETETRAZOLE;MAXIMALELECTROSHOCK

Abstract

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world. Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In thispaper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3, 5-dicarboxamides was performed. Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetrazoleand maximal electroshock induced seizures tests. Nifedipine was used as reference drug. Ourpharmacological results revealing the compounds 2, 4, 5, and 6 can be effective in both absenceand grandmal seizures in human. These pharmacological studies have displayed that these new dihydropyridine derivativesare capable to inhibiting seizures induced by pentylenetetrazole and maximal electroshock inmice efficiently.

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APA: Copy

RASOULI, YASAMAN, DAVOOD, ASGHAR, ALAEE, ARMIN, DEHQANI, GOLNOUSH, SHAFAROUDI, HAMED, LOTFINIA, MAHBOUBEH, AMINI, MOHSEN, & SHAFIEE, ABBAS. (2017). ANTICONVULSANT EFFECTS OF NEW 1, 4-DIHYDROPYRIDINEDERIVATIVESCONTAINING IMIDAZOLYL MOIETY AGAINST SEIZURES INDUCED BYPENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 893-903. SID. https://sid.ir/paper/288992/en

Vancouver: Copy

RASOULI YASAMAN, DAVOOD ASGHAR, ALAEE ARMIN, DEHQANI GOLNOUSH, SHAFAROUDI HAMED, LOTFINIA MAHBOUBEH, AMINI MOHSEN, SHAFIEE ABBAS. ANTICONVULSANT EFFECTS OF NEW 1, 4-DIHYDROPYRIDINEDERIVATIVESCONTAINING IMIDAZOLYL MOIETY AGAINST SEIZURES INDUCED BYPENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):893-903. Available from: https://sid.ir/paper/288992/en

IEEE: Copy

YASAMAN RASOULI, ASGHAR DAVOOD, ARMIN ALAEE, GOLNOUSH DEHQANI, HAMED SHAFAROUDI, MAHBOUBEH LOTFINIA, MOHSEN AMINI, and ABBAS SHAFIEE, “ANTICONVULSANT EFFECTS OF NEW 1, 4-DIHYDROPYRIDINEDERIVATIVESCONTAINING IMIDAZOLYL MOIETY AGAINST SEIZURES INDUCED BYPENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK IN MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 893–903, 2017, [Online]. Available: https://sid.ir/paper/288992/en

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