FLUOXETINE REGULATES IG KAPPA CHAIN C REGION EXPRESSION LEVELS IN THE SERUM OF OBSESSIVE-COMPULSIVE DISORDER PATIENTS: A PROTEOMIC APPROACH

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ZAMANIAN AZODI MONA; REZAEI TAVIRANI MOSTAFA; AREFI OSKOUIE AFSANEH; HAMDIEH MOSTAFA; DERAKHSHAN MOHAMMAD KAMRAN; AHMADZADEH ALIREZA; ZAYERI FARID; NEJADI NASER; REZAEI TAVIRANI MAJID; MANSOURI VAHID; ROSTAMI NEJAD MOHAMMAD; VAFAEE REZA

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1264-1271

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Title

FLUOXETINE REGULATES IG KAPPA CHAIN C REGION EXPRESSION LEVELS IN THE SERUM OF OBSESSIVE-COMPULSIVE DISORDER PATIENTS: A PROTEOMIC APPROACH

Author(s)

Keywords

OBSESSIVE-COMPULSIVE DISORDER

WASHING SUBTYPE

FLUOXETINE

IG KAPPACHAIN C REGION

PROTEOMICS

INTERACTOME ANALYSIS

Abstract

OBSESSIVE-COMPULSIVE DISORDER (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexityof OCD underlying mechanisms. Here, by the application gel-based proteomic approach theproteome profile of patients with WASHING SUBTYPE of OCD before and after treatment withFLUOXETINE (positive responders) are compared to healthy matched controls. However, only oneof the differentially expressed proteins is examined and introduced in this paper. Proteomicanalysis was done by the application of two-dimensional polyacrylamide gel electrophoresis(2-D PAGE), combined with (MALDI-TOF-TOF MS)-based. Furthermore, network analysisand biological annotation were handled by Cytoscape Plug-in and CluePedia. The proteomecomparison between groups identified protein with the significant expression changes (p<0. 05and fold change ≥ 1. 5). While the expression level of Ig Kappa Chain C Region is significantlydecreased in OCD patients before any treatments, the trend is almost normalized after treatmentwith FLUOXETINE in positive responders. In addition, interaction profile of IGKC shows thatthe interacting proteins may be affected as the expression pattern of IGKC changes in OCDpatients. In conclusion, IGKC may be introduced as potential biomarker in our study; yet, investigation in bigger sample size and application of validation methods is a requirement.

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APA: Copy

ZAMANIAN AZODI, MONA, REZAEI TAVIRANI, MOSTAFA, AREFI OSKOUIE, AFSANEH, HAMDIEH, MOSTAFA, DERAKHSHAN, MOHAMMAD KAMRAN, AHMADZADEH, ALIREZA, ZAYERI, FARID, NEJADI, NASER, REZAEI TAVIRANI, MAJID, MANSOURI, VAHID, ROSTAMI NEJAD, MOHAMMAD, & VAFAEE, REZA. (2017). FLUOXETINE REGULATES IG KAPPA CHAIN C REGION EXPRESSION LEVELS IN THE SERUM OF OBSESSIVE-COMPULSIVE DISORDER PATIENTS: A PROTEOMIC APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1264-1271. SID. https://sid.ir/paper/288994/en

Vancouver: Copy

ZAMANIAN AZODI MONA, REZAEI TAVIRANI MOSTAFA, AREFI OSKOUIE AFSANEH, HAMDIEH MOSTAFA, DERAKHSHAN MOHAMMAD KAMRAN, AHMADZADEH ALIREZA, ZAYERI FARID, NEJADI NASER, REZAEI TAVIRANI MAJID, MANSOURI VAHID, ROSTAMI NEJAD MOHAMMAD, VAFAEE REZA. FLUOXETINE REGULATES IG KAPPA CHAIN C REGION EXPRESSION LEVELS IN THE SERUM OF OBSESSIVE-COMPULSIVE DISORDER PATIENTS: A PROTEOMIC APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1264-1271. Available from: https://sid.ir/paper/288994/en

IEEE: Copy

MONA ZAMANIAN AZODI, MOSTAFA REZAEI TAVIRANI, AFSANEH AREFI OSKOUIE, MOSTAFA HAMDIEH, MOHAMMAD KAMRAN DERAKHSHAN, ALIREZA AHMADZADEH, FARID ZAYERI, NASER NEJADI, MAJID REZAEI TAVIRANI, VAHID MANSOURI, MOHAMMAD ROSTAMI NEJAD, and REZA VAFAEE, “FLUOXETINE REGULATES IG KAPPA CHAIN C REGION EXPRESSION LEVELS IN THE SERUM OF OBSESSIVE-COMPULSIVE DISORDER PATIENTS: A PROTEOMIC APPROACH,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1264–1271, 2017, [Online]. Available: https://sid.ir/paper/288994/en

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