مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE EVALUATION AND COMPARING OF CYTOTOXIC EFFECTS OF FERULA GUMMOSA GUM, SCUTELLARIA LINDBERGII, KELUSSIA ODORATISSIMA AND ARTEMISIA KOPETDAGHENSIS EXTRACTS ON ACHN CELL LINE

Pages

  1104-1112

Abstract

 Renal cell carcinoma (RCC) is one of most fatal cancers. In most patients it is resistantto chemotherapy. FERULA GUMMOSA GUM, SCUTELLARIA LINDBERGII, KELUSSIA ODORATISSIMA, andARTEMISIA KOPETDAGHENSIS are herbs about which there are some cytotoxic activity reports. Inthis study, cytotoxic and apoptotic activity of these four extracts on RCC cell line (ACHN)were evaluated and compared (ACHN) cells were treated with different concentrations ofherbal extracts (15-500 μ g/mL). Cell proliferation was determined after 24, 48, and 72 h. byMTT assay. Apoptotic cells were determined using PI staining of DNA fragmentation by flowcytometry. Cell viability decreased with all herbal extracts in ACHN cells by 24, 48, and 72h. as compared with control. Extracts induced a sub-G1 peak in flow cytometry histogram oftreated cells indicating apoptotic cell death is involved in extracts induced-toxicity. Resultsimply that four herbal extracts inhibit the growth of ACHN cells as a concentration-and timedependentmanner. Also, results show that APOPTOSIS is proposed as the possible mechanismof action. So, four herbal extracts could be considered as good anticancer agents in RCC afterfurther studies.

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    APA: Copy

    HOSSEINI, AZAR, BAKHTIARI, ELHAM, KHAJAVI RAD, ABOLFAZL, Shahraki, Samira, MOUSAVI, SEYED HADI, HAVAKHAH, SHAHRZAD, & AMIRI, MOHAMMAD SADEGH. (2017). THE EVALUATION AND COMPARING OF CYTOTOXIC EFFECTS OF FERULA GUMMOSA GUM, SCUTELLARIA LINDBERGII, KELUSSIA ODORATISSIMA AND ARTEMISIA KOPETDAGHENSIS EXTRACTS ON ACHN CELL LINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1104-1112. SID. https://sid.ir/paper/289005/en

    Vancouver: Copy

    HOSSEINI AZAR, BAKHTIARI ELHAM, KHAJAVI RAD ABOLFAZL, Shahraki Samira, MOUSAVI SEYED HADI, HAVAKHAH SHAHRZAD, AMIRI MOHAMMAD SADEGH. THE EVALUATION AND COMPARING OF CYTOTOXIC EFFECTS OF FERULA GUMMOSA GUM, SCUTELLARIA LINDBERGII, KELUSSIA ODORATISSIMA AND ARTEMISIA KOPETDAGHENSIS EXTRACTS ON ACHN CELL LINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1104-1112. Available from: https://sid.ir/paper/289005/en

    IEEE: Copy

    AZAR HOSSEINI, ELHAM BAKHTIARI, ABOLFAZL KHAJAVI RAD, Samira Shahraki, SEYED HADI MOUSAVI, SHAHRZAD HAVAKHAH, and MOHAMMAD SADEGH AMIRI, “THE EVALUATION AND COMPARING OF CYTOTOXIC EFFECTS OF FERULA GUMMOSA GUM, SCUTELLARIA LINDBERGII, KELUSSIA ODORATISSIMA AND ARTEMISIA KOPETDAGHENSIS EXTRACTS ON ACHN CELL LINE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1104–1112, 2017, [Online]. Available: https://sid.ir/paper/289005/en

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