TRUNCATED FORMS OF RUNX3 UNLIKE FULL LENGTH PROTEIN ALTER CELL PROLIFERATION IN A TGF-β CONTEXT DEPENDENT MANNER

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RAHMANIAN NARGES; TARIGHI PARASTOO; Gharghabi Mehdi; TORSHABI MARYAM; TARFIEI GHORBAN ALI; MOHAMMADI FARSANI TAIEBEH; OSTAD SEYED NASER; GHAHREMANI MOHAMMAD HOSSEIN

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 1194-1203

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Title

TRUNCATED FORMS OF RUNX3 UNLIKE FULL LENGTH PROTEIN ALTER CELL PROLIFERATION IN A TGF-β CONTEXT DEPENDENT MANNER

Author(s)

Keywords

RUNT

CANCER

TGF-β

DOMAIN ANALYSIS

APOPTOSIS

Abstract

The RUNT related transcription factors (RUNX) are recognized as key players in suppressingor promoting tumor growth. RUNX3, a member of this family, is known as a tumor suppressorin many types of CANCERs, although such a paradigm was challenged by some researchers. TheTGF-β; pathway governs major upstream signals to activate RUNX3. RUNX3 protein consistsof several regions and domains. The RUNT domain is a conserved DNA binding domain andis considered as the main part of RUNX proteins. Herein, we compared the effects of RUNTdomains and full-Runx3 in cell viability by designing two constructs of Runx3, includingN-terminal region and RUNT domain. We investigated the effect of full-Runx3, N-t, and RD ongrowth inhibition in AGS, MCF-7, A549, and HEK293 cell lines which are different in TGF-β; sensitivity, in the absence and presence of TGF-β; . The full length RUNX3 did not notablyinhibit growth of these cell lines while, the N-t and RD truncates showed different trends inthese cell lines. Cell proliferation in the TGF-β; impaired context cell lines (AGS and MCF-7)significantly decrease while in the A549 significantly increase. On the other hand, transfectionof N-t and RD did not considerably affect the cell proliferation in the HEK293. Our results showthat full-lenght RUNX3 did not affect the cell viability. Conversely, the N-t and RD constructssignificantly changed cell proliferation. Therefore, therapeutic potentials for these truncatedproteins are suggested in tumors with RUNX proteins dysfunction, even in the TGF-β; impaircontext.

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APA: Copy

RAHMANIAN, NARGES, TARIGHI, PARASTOO, Gharghabi, Mehdi, TORSHABI, MARYAM, TARFIEI, GHORBAN ALI, MOHAMMADI FARSANI, TAIEBEH, OSTAD, SEYED NASER, & GHAHREMANI, MOHAMMAD HOSSEIN. (2017). TRUNCATED FORMS OF RUNX3 UNLIKE FULL LENGTH PROTEIN ALTER CELL PROLIFERATION IN A TGF-β CONTEXT DEPENDENT MANNER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 1194-1203. SID. https://sid.ir/paper/289006/en

Vancouver: Copy

RAHMANIAN NARGES, TARIGHI PARASTOO, Gharghabi Mehdi, TORSHABI MARYAM, TARFIEI GHORBAN ALI, MOHAMMADI FARSANI TAIEBEH, OSTAD SEYED NASER, GHAHREMANI MOHAMMAD HOSSEIN. TRUNCATED FORMS OF RUNX3 UNLIKE FULL LENGTH PROTEIN ALTER CELL PROLIFERATION IN A TGF-β CONTEXT DEPENDENT MANNER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):1194-1203. Available from: https://sid.ir/paper/289006/en

IEEE: Copy

NARGES RAHMANIAN, PARASTOO TARIGHI, Mehdi Gharghabi, MARYAM TORSHABI, GHORBAN ALI TARFIEI, TAIEBEH MOHAMMADI FARSANI, SEYED NASER OSTAD, and MOHAMMAD HOSSEIN GHAHREMANI, “TRUNCATED FORMS OF RUNX3 UNLIKE FULL LENGTH PROTEIN ALTER CELL PROLIFERATION IN A TGF-β CONTEXT DEPENDENT MANNER,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 1194–1203, 2017, [Online]. Available: https://sid.ir/paper/289006/en

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