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Information Journal Paper

Title

SRL-Coated PAMAM Dendrimer Nano-Carrier for Targeted Gene Delivery to the Glioma Cells and Competitive Inhibition by Lactoferrin

Pages

  629-640

Abstract

 Glioma, as a primary tumor of central nervous system, is the main cause of death in patients with brain cancer. Therefore, development of an efficient strategy for treatment of glioma is worthy. The aim of the current study was to develop a SRL peptide-coated dendrimer as a novel dual Gene delivery system for targeting the LRP receptor, an up-regulated gene in both BBB and glioma cells. To perform this investigation, our newly developed nanocarrier (PAMAM-PEG-SRL) was used for Gene delivery to C6 glioma cell lines. DNA (GFP) was loaded in these functionalized nanoparticles and their cellular uptake/distribution and gene transfection efficacy was evaluated by fluorescence and confocal microscopy. In vitro studies showed that SRL-modified nanoparticles have good transfection efficacy. Results revealed improved gene transfection efficiency of newly-synthesized delivery system. We also found that lactoferrin, as a LRP ligand, reduced the gene transfection efficacy of the delivery system due to its higher affinity compared to SRL peptides (Competitive inhibition). The present results suggest that the synthesized delivery system has the potential to be used as an alternative targeted drug delivery system for Brain tumors.

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    APA: Copy

    zarebkohan, Amir, NAJAFI, FARHOOD, MOGHIMI, HAMID REZA, HEMMATI, MOHAMMAD, DEEVBAND, MOHAMAD REZA, & KAZEMI, BAHRAM. (2016). SRL-Coated PAMAM Dendrimer Nano-Carrier for Targeted Gene Delivery to the Glioma Cells and Competitive Inhibition by Lactoferrin. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 629-640. SID. https://sid.ir/paper/289048/en

    Vancouver: Copy

    zarebkohan Amir, NAJAFI FARHOOD, MOGHIMI HAMID REZA, HEMMATI MOHAMMAD, DEEVBAND MOHAMAD REZA, KAZEMI BAHRAM. SRL-Coated PAMAM Dendrimer Nano-Carrier for Targeted Gene Delivery to the Glioma Cells and Competitive Inhibition by Lactoferrin. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):629-640. Available from: https://sid.ir/paper/289048/en

    IEEE: Copy

    Amir zarebkohan, FARHOOD NAJAFI, HAMID REZA MOGHIMI, MOHAMMAD HEMMATI, MOHAMAD REZA DEEVBAND, and BAHRAM KAZEMI, “SRL-Coated PAMAM Dendrimer Nano-Carrier for Targeted Gene Delivery to the Glioma Cells and Competitive Inhibition by Lactoferrin,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 629–640, 2016, [Online]. Available: https://sid.ir/paper/289048/en

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