An In-vitro Investigation of Swelling Controlled Delivery of Insulin from Egg Albumin Nanocarriers

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Mahobia Swati; BAJPAI JAYA; BAJPAI ANIL KUMAR

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:4 Page(s): 695-711

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Information Journal Paper

Title

An In-vitro Investigation of Swelling Controlled Delivery of Insulin from Egg Albumin Nanocarriers

Author(s)

Mahobia Swati | BAJPAI JAYA | BAJPAI ANIL KUMAR | Issue Writer Certificate

Keywords

Egg albumin

Insulin

Nanocarriers

Biopolymers

Abstract

The aim of the present work was to prepare and characterize biopolymer Nanocarriers and evaluate their suitability in possible oral delivery of Insulin. The Egg albumin biopolymer was used to prepare nanoparticles which were further characterized by Fourier transformed Infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), zeta potential, Dynamic Light scattering (DLS) and cytotoxicity. From the characterization studies the size of the nanoparticles washemoly found to lie in the range 20-80 nm with surface charge of-23 mV and also offering extremely fair biocompatibility. . The in-vitro biocompatibility of the prepared Nanocarriers was judged by BSA adsorption test and haemolysis assay. The in vitro release kinetics of the Insulin loaded nanoparticles was studied in phosphate buffer saline (PBS) solution, and the influence of various factors such as pH, temperature and simulated physiological fluids was studied on the controlled release of Insulin.

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APA: Copy

Mahobia, Swati, BAJPAI, JAYA, & BAJPAI, ANIL KUMAR. (2016). An In-vitro Investigation of Swelling Controlled Delivery of Insulin from Egg Albumin Nanocarriers. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 695-711. SID. https://sid.ir/paper/289062/en

Vancouver: Copy

Mahobia Swati, BAJPAI JAYA, BAJPAI ANIL KUMAR. An In-vitro Investigation of Swelling Controlled Delivery of Insulin from Egg Albumin Nanocarriers. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):695-711. Available from: https://sid.ir/paper/289062/en

IEEE: Copy

Swati Mahobia, JAYA BAJPAI, and ANIL KUMAR BAJPAI, “An In-vitro Investigation of Swelling Controlled Delivery of Insulin from Egg Albumin Nanocarriers,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 695–711, 2016, [Online]. Available: https://sid.ir/paper/289062/en

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