Interaction of mTOR and iNOS pathways in protection against Ischemia/ Reperfusion injury

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ARABIAN MAEDEH; ABOUTALEB NAHID; AJAMI MARJAN; HABIBEY ROUHOLLAH

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:2 Page(s): 785-792

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Title

Interaction of mTOR and iNOS pathways in protection against Ischemia/ Reperfusion injury

Author(s)

ARABIAN MAEDEH | ABOUTALEB NAHID | AJAMI MARJAN | HABIBEY ROUHOLLAH | Issue Writer Certificate

Keywords

Ischemia/reperfusion

Morphine

iNOS

Oxidative stress

Malondialdehyde

Rapamycin

mTOR

Abstract

Chronic Morphine (CM) treatment increases the phosphorylation of the mammalian target of Rapamycin (mTOR), which confers neuroprotection against Ischemia/reperfusion (I/R) injury. Besides its important regulatory role in the proliferation, metabolism, and survival of cells, the mTOR is critically involved in intracellular signaling events during I/R injury. In the present study, we investigated the interaction between the expressions of the mTOR and inducible nitric oxide synthase (iNOS) and their possible protective effects on hippocampal neurons against I/R injury in Morphine-dependent mice. Additive doses of Morphine were administered for 5 days to BALB/c mice so as to induce CM preconditioning before I/R injury. Global brain ischemia was induced via the occlusion of bilateral common carotid arteries for 30 min. CM attenuated iNOS expression, NO production, and Malondialdehyde activity in the hippocampal tissue. Pretreatment with Rapamycin, the inhibitor of mTOR, abolished all the above mentioned effects of CM. These findings suggested that CM acted through the mTOR signaling pathways to regulate iNOS expression and oxidative state in the hippocampal tissue after I/R injury.

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APA: Copy

ARABIAN, MAEDEH, ABOUTALEB, NAHID, AJAMI, MARJAN, & HABIBEY, ROUHOLLAH. (2019). Interaction of mTOR and iNOS pathways in protection against Ischemia/ Reperfusion injury. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(2), 785-792. SID. https://sid.ir/paper/289089/en

Vancouver: Copy

ARABIAN MAEDEH, ABOUTALEB NAHID, AJAMI MARJAN, HABIBEY ROUHOLLAH. Interaction of mTOR and iNOS pathways in protection against Ischemia/ Reperfusion injury. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(2):785-792. Available from: https://sid.ir/paper/289089/en

IEEE: Copy

MAEDEH ARABIAN, NAHID ABOUTALEB, MARJAN AJAMI, and ROUHOLLAH HABIBEY, “Interaction of mTOR and iNOS pathways in protection against Ischemia/ Reperfusion injury,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 2, pp. 785–792, 2019, [Online]. Available: https://sid.ir/paper/289089/en

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