Anti-Asthma Effect of an Active Components Group from Decoction of Pheretima Aspergillum and Its Chemical Composition Characterized by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry

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Shi Qingxin; Wang Xuanyuan; Liu Junyi; Xiang Xingliang; Su Mingwu; Huang Rongzeng; SONG CHENGWU

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:2 Page(s): 867-876

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Title

Anti-Asthma Effect of an Active Components Group from Decoction of Pheretima Aspergillum and Its Chemical Composition Characterized by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry

Author(s)

Keywords

Asthma

Pheretima aspergillum

Oligopeptides

Active components group

LC-QTOF-MS/MS

Abstract

The decoction of Pheretima aspergillum is used as a traditional medicine for treatment of Asthma in China with a long clinical history. The aim of the study was to investigate the antiAsthma activities of an Active components group obtained from the decoction of Pheretima aspergillum in histamine and ovalubumin induced Asthma guinea pigs. The experimental Asthma model was established with spray of histamine and ovalbumin (OVA) followed by intragastric administration of Pheretima aspergillum extract and fractions. The incubation period of Asthma, serum IFN-γ , IL-4, and LTB4 levels were tested and determined. In addition, liquid chromatography-quadrupole time of flight mass spectrometry (LC-QTOF-MS/MS) was used to identify the bioactive components in active fraction. The significant increase of Asthma incubation period, serum IFN-γ level were observed in the Asthma guinea pigs treated with the Active components group. The serum IL-4 and LTB4 levels were obviously decreased compared to that of model controls. In addition, twenty Oligopeptides were first identified or characterized in the active fraction from the decoction of Pheretima aspergillum. The results indicated that Pheretima aspergillum can inhibit infiltration and diffusion of inflammatory cells in Asthma model guinea pigs, and regulate IFN-γ , IL-4, and LTB4 secretions. It is reasonable to assume that the anti-Asthma activities of Pheretima aspergillum mainly resulted from these Oligopeptides. Also, synergistic effects among their compounds may exist in the anti-Asthma activity of Pheretima aspergillum.

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APA: Copy

Shi, Qingxin, Wang, Xuanyuan, Liu, Junyi, Xiang, Xingliang, Su, Mingwu, Huang, Rongzeng, & SONG, CHENGWU. (2019). Anti-Asthma Effect of an Active Components Group from Decoction of Pheretima Aspergillum and Its Chemical Composition Characterized by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(2), 867-876. SID. https://sid.ir/paper/289099/en

Vancouver: Copy

Shi Qingxin, Wang Xuanyuan, Liu Junyi, Xiang Xingliang, Su Mingwu, Huang Rongzeng, SONG CHENGWU. Anti-Asthma Effect of an Active Components Group from Decoction of Pheretima Aspergillum and Its Chemical Composition Characterized by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(2):867-876. Available from: https://sid.ir/paper/289099/en

IEEE: Copy

Qingxin Shi, Xuanyuan Wang, Junyi Liu, Xingliang Xiang, Mingwu Su, Rongzeng Huang, and CHENGWU SONG, “Anti-Asthma Effect of an Active Components Group from Decoction of Pheretima Aspergillum and Its Chemical Composition Characterized by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 2, pp. 867–876, 2019, [Online]. Available: https://sid.ir/paper/289099/en

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