Comparison of Two Different Techniques Of Warfarin Dosing Determination-A Chemometrics Study

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Makohusova Miroslava; Mrazova Viera; Bednarova Adriana; Milatova Eva; Sokol Jozef; Plesko Marek; Batorova Angelika

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:2 Page(s): 1010-1019

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Title

Comparison of Two Different Techniques Of Warfarin Dosing Determination-A Chemometrics Study

Author(s)

Keywords

Warfarin dose

Pharmacogenetics

Gene polymorphisms

Passing-Bablock regression

Bland-Altman method

Abstract

A high prevalence of genetic polymorphisms increases sensitivity to warfarin therapy. In this study, we investigated 47 patients with effective long-term therapy by warfarin wellcontrolled by monitoring of International Normalised Ratio (INR). All patients were tested for Gene polymorphisms VKORC1, CYP2C9*C2, and CYP2C9*C3, which were used for a dose calculation employing a program www. WarfarinDosing. org. The main goal was to investigate whether the Warfarin doses determined by INR are in accordance with the doses calculated according to the pharmacogenetic algorithm. For this purpose, several chemometric tools, namely principal component analysis, cluster analysis, correlation analysis, correspondence analysis, Passing-Bablock regression, Bland-Altman method, descriptive statistics, and ANOVA were used. We also analysed the relationship between the dose of warfarin determined by INR and several constitutional and genetic factors. Statistically significant association between clinically optimized Warfarin dose and indication for the treatment, age, and warfarin sensitivity determined by VKORC1, CYP2C9 Gene polymorphisms were confirmed. Finally, we confirmed a good concordance between the INR determined Warfarin doses and pharmacogenetic approach.

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APA: Copy

Mrazova, Viera, Bednarova, Adriana, Milatova, Eva, Sokol, Jozef, Plesko, Marek, & Batorova, Angelika. (2019). Comparison of Two Different Techniques Of Warfarin Dosing Determination-A Chemometrics Study. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(2), 1010-1019. SID. https://sid.ir/paper/289112/en

Vancouver: Copy

Mrazova Viera, Bednarova Adriana, Milatova Eva, Sokol Jozef, Plesko Marek, Batorova Angelika. Comparison of Two Different Techniques Of Warfarin Dosing Determination-A Chemometrics Study. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(2):1010-1019. Available from: https://sid.ir/paper/289112/en

IEEE: Copy

Viera Mrazova, Adriana Bednarova, Eva Milatova, Jozef Sokol, Marek Plesko, and Angelika Batorova, “Comparison of Two Different Techniques Of Warfarin Dosing Determination-A Chemometrics Study,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 2, pp. 1010–1019, 2019, [Online]. Available: https://sid.ir/paper/289112/en

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