Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

167
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

160
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Evaluation of the Protective Effects of Doxycycline on Acetaminophen-Induced Hepatotoxicity in Mice

Pages

  704-712

Abstract

 Acetaminophen (APAP) toxicity threatens human health due to increased mortality associated with its overdose. Doxycycline (DC) because of its properties such as antioxidant and anti-inflammatory can be a good therapeutic strategy to treat the acute toxicity induced by APAP. Male Mice were divided into six groups in two periods of 3 h and 24 h as normal saline, APAP 400 mg/kg, DC 100 mg/kg and groups treated by 25, 50 and 100 mg/kg DC just before APAP, respectively. At the end of the 3 h and 24 h periods, the hepatic index, biochemical parameters including serum aspartate transaminase (AST) and alanine transaminase (ALT) activity and hepatic catalase activity, glutathione (GSH) and malondialdehyde (MDA) levels in liver and histopathological changes were evaluated. The results indicated that DC had no apparent effect on the hepatic index but significantly normalized the level of biochemical parameters and reduced APAP induced liver damage. Overall, it could be concluded that DC can inhibit or resolve harmful effects of APAP through antioxidant and anti-inflammatory properties. However, more studies are needed to understand exact mechanism of DC and its application for clinical use.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Soltani, Shirin, KHODAYAR, MOHAMMAD JAVAD, YAGHOOTI, HAMID, Salehcheh, Maryam, MANSOURI, ESRAFIL, Zeidooni, Leila, DEHBASHI, FERESHTEH, & SAMIMI, AZIN. (2019). Evaluation of the Protective Effects of Doxycycline on Acetaminophen-Induced Hepatotoxicity in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(2), 704-712. SID. https://sid.ir/paper/289126/en

    Vancouver: Copy

    Soltani Shirin, KHODAYAR MOHAMMAD JAVAD, YAGHOOTI HAMID, Salehcheh Maryam, MANSOURI ESRAFIL, Zeidooni Leila, DEHBASHI FERESHTEH, SAMIMI AZIN. Evaluation of the Protective Effects of Doxycycline on Acetaminophen-Induced Hepatotoxicity in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(2):704-712. Available from: https://sid.ir/paper/289126/en

    IEEE: Copy

    Shirin Soltani, MOHAMMAD JAVAD KHODAYAR, HAMID YAGHOOTI, Maryam Salehcheh, ESRAFIL MANSOURI, Leila Zeidooni, FERESHTEH DEHBASHI, and AZIN SAMIMI, “Evaluation of the Protective Effects of Doxycycline on Acetaminophen-Induced Hepatotoxicity in Mice,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 2, pp. 704–712, 2019, [Online]. Available: https://sid.ir/paper/289126/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top