Mathematical Modeling and Release Kinetics of Green Tea Polyphenols Released from Casein Nanoparticles

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Prakash Upputuri Ravi Theaj; Azad Mandal Abul Kalam

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1137-1146

Download Full-Text

View:

237

Download:

214

Cites:

Information Journal Paper

Title

Mathematical Modeling and Release Kinetics of Green Tea Polyphenols Released from Casein Nanoparticles

Author(s)

Prakash Upputuri Ravi Theaj | Azad Mandal Abul Kalam | Issue Writer Certificate

Keywords

Anomalous transport

Casein nanoparticles

Green tea polyphenols

Mathematical modeling

Sustained release

Zero order kinetics

Abstract

Drug release kinetics plays an important role in determining the mechanism of drug release, which in turn helps in formulating controlled/Sustained release formulations. In our study, different concentrations of Green tea polyphenols (GTP) were encapsulated into Casein nanoparticles which showed a maximum encapsulation efficiency (76. 9%) at a GTP concentration of 5 mg/mL. The Casein nanoparticles were characterized through particle size analysis, zeta potential, AFM, and HR SEM, followed by molecular docking studies, which confirmed the binding of GTP to Casein nanoparticles. In-vitro release studies carried out at different temperatures and pH showed no significant difference in the release pattern, but the release was prolonged even up to 48 h. On varying pH of the release medium, an increase in the percentage of release was observed as the pH shifted from acidic to basic. All release data showed good correlation with Zero order kinetics, an ideal model for release of drugs from nanoparticulate Sustained release formulations, with anomalous mode of drug transport. Antioxidant activity of the released GTP determined through DPPH assay showed potent antioxidant effect of GTP even after 48 h of its release. Our data indicated that Casein nanoparticles could be used as a potent vehicle for the delivery of GTP for achieving a Sustained release.

Cites

No record.

References

No record.

Cite

APA: Copy

Prakash Upputuri, Ravi Theaj, & Azad Mandal, Abul Kalam. (2019). Mathematical Modeling and Release Kinetics of Green Tea Polyphenols Released from Casein Nanoparticles. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1137-1146. SID. https://sid.ir/paper/289142/en

Vancouver: Copy

Prakash Upputuri Ravi Theaj, Azad Mandal Abul Kalam. Mathematical Modeling and Release Kinetics of Green Tea Polyphenols Released from Casein Nanoparticles. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1137-1146. Available from: https://sid.ir/paper/289142/en

IEEE: Copy

Ravi Theaj Prakash Upputuri, and Abul Kalam Azad Mandal, “Mathematical Modeling and Release Kinetics of Green Tea Polyphenols Released from Casein Nanoparticles,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1137–1146, 2019, [Online]. Available: https://sid.ir/paper/289142/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops