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Information Journal Paper

Title

Anti-Inflammatory and Anti-Oxidative Effects of Myrtenol in the Rats with Allergic Asthma

Pages

  1488-1498

Abstract

 The aim of the present study was to investigate the effect of Myrtenol, the active ingredient of Myrtle on the oxidant and anti-oxidant indices and Cytokines in the Allergic asthma. Allergic asthma was induced by ovalbumin (OVA) sensitization and inhalation in four groups of rats; Control, Asthma, Asthma + Dexamethasone and Asthma + Myrtenol. Myrtenol (50mg/kg) or Dexamethasone (2. 5mg/kg) was administered intraperitoneally for 7 consecutive days after OVA inhalation. At the end, histopathological parameters, and interleukins (Interleukin-10 (IL10), Interferon gamma (IFN-γ ), interleukin-1β (IL-1β ), Tumor Necrosis Factor α (TNF-α )), and oxidative stress biomarkers, Malondialdehyde (MDA), Superoxide dismutase (SOD) and Glutathione peroxidase (GPX) in the lung and serum were measured by hematoxylin and eosin staining and ELISA method, respectively. Myrtenol reduced the pathological changes in the lungs and airway endothelium (P < 0. 01), (P < 0. 5). The level of IL-1β (P < 0. 05) and MDA in the serum and lung tissue (P < 0. 01), (P < 0. 05), and also the level of TNF-α (P < 0. 05) in the lung tissue decreased in the Myrtenol group compared to the asthma group. Myrtenol increased the level of IL-10 (P < 0. 05) and the activity of GPX in the lung tissue and serum (P < 0. 001). Myrtenol may improve asthma by increasing the ratio of antioxidants to oxidants and reducing the ratio of pro-inflammatory to anti-inflammatory interleukins in the lung. Myrtenol is presented as a potent herbal medicine ingredient for the treatment of asthma.

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    APA: Copy

    Rajizadeh, Mohammad Amin, NAJAFIPOUR, HAMID, SAMAREH FEKRI, MITRA, Rostamzadeh, Farzaneh, JAFARI, ELHAM, Bejeshk, Mohammad Abbas, & MASOUMI ARDAKANI, YASER. (2019). Anti-Inflammatory and Anti-Oxidative Effects of Myrtenol in the Rats with Allergic Asthma. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1488-1498. SID. https://sid.ir/paper/289145/en

    Vancouver: Copy

    Rajizadeh Mohammad Amin, NAJAFIPOUR HAMID, SAMAREH FEKRI MITRA, Rostamzadeh Farzaneh, JAFARI ELHAM, Bejeshk Mohammad Abbas, MASOUMI ARDAKANI YASER. Anti-Inflammatory and Anti-Oxidative Effects of Myrtenol in the Rats with Allergic Asthma. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1488-1498. Available from: https://sid.ir/paper/289145/en

    IEEE: Copy

    Mohammad Amin Rajizadeh, HAMID NAJAFIPOUR, MITRA SAMAREH FEKRI, Farzaneh Rostamzadeh, ELHAM JAFARI, Mohammad Abbas Bejeshk, and YASER MASOUMI ARDAKANI, “Anti-Inflammatory and Anti-Oxidative Effects of Myrtenol in the Rats with Allergic Asthma,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1488–1498, 2019, [Online]. Available: https://sid.ir/paper/289145/en

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