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Information Journal Paper

Title

The Protective Effect of Auraptene Against Oxidative Stress and Pentylenetetrazol-Induced Chemical Kindling in Mice

Pages

  1395-1402

Abstract

 It is believed that some pitfalls in the treatment of epilepsy such as serious side effects of medications and drug resistance may be resolved by natural compounds. Auraptene belongs to coumarins and is found in citrus peel. We hypothesized that Auraptene might have anticonvulsant properties. Kindling was induced by repeated intraperitoneal (IP) injections of Pentylenetetrazol (PTZ, 35 mg/kg) with two-day intervals for 24 days in male albino mice. Three groups received IP injections of Auraptene (12. 5, 25, and 50 mg/kg). Three control groups received vehicle, diazepam (3 mg/kg, IP), and vitamin E (150 mg/kg, IP). Seizurerelated behaviors were recorded for 30 min after PTZ injection. Moreover, malondialdehyde and reduced glutathione (GSH) were measured in the brain. The results indicated that Auraptene at the dose of 12. 5 mg/kg and vitamin E significantly prolonged the latency to stage 2 of Seizures (P < 0. 01). Auraptene at the doses of 25 mg/kg and 50 mg/kg, prolonged the latency to stage 4 (P < 0. 01) and reduced stage 5 duration of Seizures (P < 0. 01). All doses of Auraptene reduced median of Seizure scores (P < 0. 01). The kindled control group had MDA levels similar to intact animals but had a lower concentration of GSH (P < 0. 001). None of the tested compounds changed the malondialdehyde concentration significantly. However, Auraptene at the dose of 50 mg/kg and vitamin E increased GSH levels (P < 0. 05). The results suggest that Auraptene had anticonvulsant effects in PTZ-induced Chemical kindling that was mediated by mechanisms other than the antioxidant effect of Auraptene.

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    APA: Copy

    ETEMAD, LEILA, ZAMANI, MAHDIEH, IRANSHAHI, MEHRDAD, & ROOHBAKHSH, ALI. (2019). The Protective Effect of Auraptene Against Oxidative Stress and Pentylenetetrazol-Induced Chemical Kindling in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1395-1402. SID. https://sid.ir/paper/289149/en

    Vancouver: Copy

    ETEMAD LEILA, ZAMANI MAHDIEH, IRANSHAHI MEHRDAD, ROOHBAKHSH ALI. The Protective Effect of Auraptene Against Oxidative Stress and Pentylenetetrazol-Induced Chemical Kindling in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1395-1402. Available from: https://sid.ir/paper/289149/en

    IEEE: Copy

    LEILA ETEMAD, MAHDIEH ZAMANI, MEHRDAD IRANSHAHI, and ALI ROOHBAKHSH, “The Protective Effect of Auraptene Against Oxidative Stress and Pentylenetetrazol-Induced Chemical Kindling in Mice,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1395–1402, 2019, [Online]. Available: https://sid.ir/paper/289149/en

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