Comparative of in-vitro Evaluation between Erlotinib Loaded Nanostructured Lipid Carriers and Liposomes against A549 Lung Cancer Cell Line

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Abedi Gaballu Fereydoon; Soheil Abbaspour Ravasjani; MANSOORI BEHZAD; Yekta Reza; HAMISHEHKAR HAMED; MOHAMMADI ALI; DEHGHAN GHOLAMREZA; Shokouhi Behrooz; Ghahremani Dehbokri Shaho; BARADARAN BEHZAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1168-1179

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Title

Comparative of in-vitro Evaluation between Erlotinib Loaded Nanostructured Lipid Carriers and Liposomes against A549 Lung Cancer Cell Line

Author(s)

Keywords

Erlotinib

Liposome

NLCs

A549 cells

Abstract

Erlotinib (ELT) as a small molecule with poor solubility, poor bioavailability, and instability in gastrointestinal environment, has been considered as a therapeutic agent for Non-Small-Cell Lung Cancer (NSCLC) therapy through oral administration. In the present study, ELT-Liposome and ELT-NLCs were successfully prepared and characterized by assessment of the particle size, zeta potential (ZP), polydispersity index (PDI), encapsulation efficiency (EE), and drug loading (DL). DAPI staining and Flow cytometry techniques were employed to probe anticancer activities of the optimal formulations. The obtained results indicated that the average size of optimized ELT-NLCs was 109 ± 2 nm, while the optimal formulation of ELTLiposome was 130 ± 4 nm. In addition, the values of EE, DL, and cellular uptake were higher in ELT-NLCs than ELT-Liposome. Moreover, the stability of ELT-NLCs and ELT-Liposome were not significantly changed (P > 0. 05) within storage time. The results of anti-cancer assessment indicated that ELT-NLCs caused more cell viability reduction than ELT-Liposome and free ELT. According to the Flow cytometry and DAPI staining results, the exposed A549 cells with ELT-NLCs had more rates of apoptosis than ELT-Liposome. The obtained data from this study clearly showed that ELT-NLCs had better anti-cancer activity than ELT-Liposome, which may be related to the effective nano particle size, PDI, EE, and DL of ELT-NLCs.

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APA: Copy

Abedi Gaballu, Fereydoon, Soheil, Abbaspour Ravasjani, MANSOORI, BEHZAD, Yekta, Reza, HAMISHEHKAR, HAMED, MOHAMMADI, ALI, DEHGHAN, GHOLAMREZA, Shokouhi, Behrooz, Ghahremani Dehbokri, Shaho, & BARADARAN, BEHZAD. (2019). Comparative of in-vitro Evaluation between Erlotinib Loaded Nanostructured Lipid Carriers and Liposomes against A549 Lung Cancer Cell Line. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1168-1179. SID. https://sid.ir/paper/289157/en

Vancouver: Copy

Abedi Gaballu Fereydoon, Soheil Abbaspour Ravasjani, MANSOORI BEHZAD, Yekta Reza, HAMISHEHKAR HAMED, MOHAMMADI ALI, DEHGHAN GHOLAMREZA, Shokouhi Behrooz, Ghahremani Dehbokri Shaho, BARADARAN BEHZAD. Comparative of in-vitro Evaluation between Erlotinib Loaded Nanostructured Lipid Carriers and Liposomes against A549 Lung Cancer Cell Line. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1168-1179. Available from: https://sid.ir/paper/289157/en

IEEE: Copy

Fereydoon Abedi Gaballu, Abbaspour Ravasjani Soheil, BEHZAD MANSOORI, Reza Yekta, HAMED HAMISHEHKAR, ALI MOHAMMADI, GHOLAMREZA DEHGHAN, Behrooz Shokouhi, Shaho Ghahremani Dehbokri, and BEHZAD BARADARAN, “Comparative of in-vitro Evaluation between Erlotinib Loaded Nanostructured Lipid Carriers and Liposomes against A549 Lung Cancer Cell Line,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1168–1179, 2019, [Online]. Available: https://sid.ir/paper/289157/en

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