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Information Journal Paper

Title

Tenecteplase Versus Reteplase in Acute Myocardial Infarction: A Network Meta-Analysis of Randomized Clinical Trials

Pages

  1622-1631

Abstract

 Acute myocardial infarction (AMI) is the leading cause of death throughout the world. One of the standard approaches to treatment of AMI is fibrinolysis. The study was conducted to evaluate the Clinical efficacy of Tenecteplase versus Reteplase through Network meta-analysis for AMI. Randomized trials were comprehensively searched in PubMed, Scopus, Cochrane library, and Web of Science using appropriate strategies. Quality assessment was done for the papers. The primary and secondary end-points were mortality, TIMI grade 3 flow at 90 min, death or non-fatal stroke, infarction, total stroke and major bleeding. Odds ratios (OR) were computed (95% confidence intervals). After screening 27325 records, eight articles were included with total patients of 49875 to the meta-analysis. Indirect comparison of Tenecteplase vs. Reteplase showed no significant differences in the risk of mortality (OR = 0. 98, p > 0. 05), TIMI grade 3 flow at 90 min (OR = 0. 77, p > 0. 05), death or non-fatal stroke (OR = 1. 04, p > 0. 05), infarction (OR = 1. 11, p > 0. 05), total stroke (OR = 2. 71, p > 0. 05), and major bleeding (OR = 0. 81, p > 0. 05) (all p > 0. 05). Indirect comparison suggests similar efficacy and safety of Tenecteplase and Reteplase. Hence, the use of each one of the two medicines depends on price, facility, and accessibility of the medicine.

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    • Cite

    APA: Copy

    ZIA BEHBAHANI, MAJID, NIKNAHAD, HOSSEIN, KOJURI, JAVAD, SALESI, MAHMOOD, Jafari, Mojtaba, & KESHAVARZ, KHOSRO. (2019). Tenecteplase Versus Reteplase in Acute Myocardial Infarction: A Network Meta-Analysis of Randomized Clinical Trials. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1622-1631. SID. https://sid.ir/paper/289159/en

    Vancouver: Copy

    ZIA BEHBAHANI MAJID, NIKNAHAD HOSSEIN, KOJURI JAVAD, SALESI MAHMOOD, Jafari Mojtaba, KESHAVARZ KHOSRO. Tenecteplase Versus Reteplase in Acute Myocardial Infarction: A Network Meta-Analysis of Randomized Clinical Trials. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1622-1631. Available from: https://sid.ir/paper/289159/en

    IEEE: Copy

    MAJID ZIA BEHBAHANI, HOSSEIN NIKNAHAD, JAVAD KOJURI, MAHMOOD SALESI, Mojtaba Jafari, and KHOSRO KESHAVARZ, “Tenecteplase Versus Reteplase in Acute Myocardial Infarction: A Network Meta-Analysis of Randomized Clinical Trials,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1622–1631, 2019, [Online]. Available: https://sid.ir/paper/289159/en

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