Protective Effect of Dizocilpine (MK-801) On TNBS-Induced Experimental Colitis in Mice

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MOTAGHI EHSAN; HAJHASHEMI VALIOLLAH; MAHZOUNI PARVIN; MINAIYAN MOHSEN

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1341-1350

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Title

Protective Effect of Dizocilpine (MK-801) On TNBS-Induced Experimental Colitis in Mice

Author(s)

MOTAGHI EHSAN | HAJHASHEMI VALIOLLAH | MAHZOUNI PARVIN | MINAIYAN MOHSEN | Issue Writer Certificate

Keywords

Dizocilpine

MK-801

Ulcerative colitis

Mice

NMDA

Abstract

Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in-vitro and in-vivo. The aim of present study was to evaluate the role of Dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfonic acid)-induced murine model of colitis. Dizocilpine (0. 1, 1 and 5 mg/kg) was given to Mice intraperitoneally from 24 h before induction of colitis and daily thereafter for 4 days. Dexamethasone (1 mg/kg) was used as the reference drug. Colitis was induced by intracolonic administration of TNBS/Ethanol (50/50 v/v, 40mg/kg). Animals were sacrificed 5 days after colitis induction and distal colons were examined macroscopically and microscopically. The colonic tissue level of pro-inflammatory cytokines including interleukin 1β (IL-1β ), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α ) were assessed by ELISA. Myeloperoxidase (MPO) level was also measured in colon. Dizocilpine, particularly with intermediate dose of 1mg/kg significantly improved animal’ s weight loss as well as macroscopic and microscopic signs of colitis, reduced colonic levels of IL-1β , IL-6, TNF-α and MPO activity. Hence, Dizocilpine has significant protective effects in TNBS-induced colitis and NMDA suppression may be a new and effective therapeutic strategy in Ulcerative colitis via decreasing in pro-inflammatory cytokine production.

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APA: Copy

MOTAGHI, EHSAN, HAJHASHEMI, VALIOLLAH, MAHZOUNI, PARVIN, & MINAIYAN, MOHSEN. (2019). Protective Effect of Dizocilpine (MK-801) On TNBS-Induced Experimental Colitis in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1341-1350. SID. https://sid.ir/paper/289161/en

Vancouver: Copy

MOTAGHI EHSAN, HAJHASHEMI VALIOLLAH, MAHZOUNI PARVIN, MINAIYAN MOHSEN. Protective Effect of Dizocilpine (MK-801) On TNBS-Induced Experimental Colitis in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1341-1350. Available from: https://sid.ir/paper/289161/en

IEEE: Copy

EHSAN MOTAGHI, VALIOLLAH HAJHASHEMI, PARVIN MAHZOUNI, and MOHSEN MINAIYAN, “Protective Effect of Dizocilpine (MK-801) On TNBS-Induced Experimental Colitis in Mice,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1341–1350, 2019, [Online]. Available: https://sid.ir/paper/289161/en

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