Chitosan-Coated Alginate Microcapsules Loaded with Herbal galactagogue Extract: Formulation Optimization and Characterization

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Khorshidian Nasim; Mahboubi Arash; KALANTARI NASER; HOSSEINI HEDAYAT; YOUSEFI MOJTABA; Arab Masoumeh; da Cruz Adriano Gomez; MORTAZAVIAN AMIR MOHAMMAD; Mahdavi Fatemeh Sadat

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1180-1195

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Title

Chitosan-Coated Alginate Microcapsules Loaded with Herbal galactagogue Extract: Formulation Optimization and Characterization

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Keywords

Galactagogues

Herbal extract

Microencapsulation

Sodium alginate

Chitosan

External gelation

Abstract

Many herbs and spices have been recommended traditionally as Galactagogues and several commercial formulations prepared using herbs. Due to the presence of various compounds such as polyphenols, flavonoids, isoflavones, and terpenes, bitter and stringent taste is elicited that make the consumption of these herbal preparations unpleasant. Moreover, these compounds are unstable when exposed to environmental conditions. In this regard, different approaches are used for taste masking such as Microencapsulation. In the present study, microcapsules containing herbal galactagogue extract were developed through emulsification/ External gelation and Box-Behnken design was used to investigate the effects of independent variables (Sodium alginate: 1-1. 5%, calcium chloride: 0. 2-1% and extract concentrations: 1-5%) on encapsulation efficiency (EE%). Following evaluation of the model, the optimum condition of encapsulation process was selected as 1. 49% Sodium alginate, 0. 84 CaCl2, and 1. 58% extract with EE% of 77. 97%. Microcapsules had an acceptable spherical morphology and the results of Fourier transform-infrared spectroscopy (FTIR) revealed the presence of the extract within the microcapsules. The mean diameters of the uncoated and Chitosan-coated microcapsules were 52 and 123 μ m and encapsulation yield was 50. 21 and 69. 7%, respectively. The polydispersity index of 0. 45 and 0. 48 were an indicative of polydisperse nature of the microcapsules. The loss of flavonoids in microcapsules stored at two different temperatures was insignificant. The in-vitro release in simulated gastric fluid (SGF; pH 1. 2) and simulated intestinal fluid (SIF; pH 7. 4) were 48. 1% and 80. 11%, respectively during 24 h. The prepared extract-loaded microcapsules have potential to be used in matrices with neutral pH.

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APA: Copy

Mahboubi, Arash, KALANTARI, NASER, HOSSEINI, HEDAYAT, YOUSEFI, MOJTABA, Arab, Masoumeh, da Cruz, Adriano Gomez, MORTAZAVIAN, AMIR MOHAMMAD, & Mahdavi, Fatemeh Sadat. (2019). Chitosan-Coated Alginate Microcapsules Loaded with Herbal galactagogue Extract: Formulation Optimization and Characterization. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1180-1195. SID. https://sid.ir/paper/289169/en

Vancouver: Copy

Mahboubi Arash, KALANTARI NASER, HOSSEINI HEDAYAT, YOUSEFI MOJTABA, Arab Masoumeh, da Cruz Adriano Gomez, MORTAZAVIAN AMIR MOHAMMAD, Mahdavi Fatemeh Sadat. Chitosan-Coated Alginate Microcapsules Loaded with Herbal galactagogue Extract: Formulation Optimization and Characterization. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1180-1195. Available from: https://sid.ir/paper/289169/en

IEEE: Copy

Arash Mahboubi, NASER KALANTARI, HEDAYAT HOSSEINI, MOJTABA YOUSEFI, Masoumeh Arab, Adriano Gomez da Cruz, AMIR MOHAMMAD MORTAZAVIAN, and Fatemeh Sadat Mahdavi, “Chitosan-Coated Alginate Microcapsules Loaded with Herbal galactagogue Extract: Formulation Optimization and Characterization,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1180–1195, 2019, [Online]. Available: https://sid.ir/paper/289169/en

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