A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKBARI DILMAGHANI NADER; ALANI NADEREH; Fazeli Sepideh

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1559-1601

Download Full-Text

View:

162

Download:

112

Cites:

Information Journal Paper

Title

A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

Author(s)

AKBARI DILMAGHANI NADER | ALANI NADEREH | Fazeli Sepideh | Issue Writer Certificate

Keywords

Chronic rhinosinusitis

Nasal polyposis

Zinc

Lund-Kennedy score

Lund-Mackay score

Abstract

Recent studies suggest a relationship between Zinc deficiency and inflammation. In the present study, we studied the effect of oral Zinc supplementation on clinical improvement of Chronic rhinosinusitis with Nasal polyposis. In this single-blind randomized controlled trial, 44 patients with Chronic rhinosinusitis with polyposis referring to ENT clinic of the Loghman Hakim hospital during 2013-2014 were randomly allocated in two groups. The treatment group (n = 28) was treated with a four-drug fixed-dose regimen (FD_FDR) consisting of oral dexamethasone (0. 02 mg/kg), fluticasone nasal spray, fexophenadine 60 mg daily, montelukast 10 mg daily plus 220mg Zinc sulfate capsules containing 55 mg elemental Zinc, b. d., and the control group (n = 16) received the FD_FDR without supplemental Zinc, for six weeks. After sixth week, two groups were compared regarding clinical outcomes based on theSNOT20 (Sinonasal outcome test) questionnaire, the general health questionnaire (SF12), the Lund-Mackay, and the Lund-Kennedy scoring systems. In the treatment group, serum Zinc levels were significantly increased compared to those at the baseline (1. 33 fold-increase; p = 0. 0002). Within groups analysis revealed a significant reduction (p < 0. 01) in LM and LK in both treatment (55% LM; 50% LK) and control groups (45% LM; 53% LK). Incontrast, between groups analysis revealed no significant differences in the LM and LK. The treatment group showed a mild superiority in general health improvement compared to that of the control group. Add-on therapy with supplemental Zinc sulfate was not associated with significant improvement in patients with Chronic rhinosinusitis with Nasal polyposis (CRSwNP). The advantage of Zinc supplementation on the general health improvement of the patients with CRSwNP requires further assessments.

Cites

No record.

References

No record.

Cite

APA: Copy

ALANI, NADEREH, & Fazeli, Sepideh. (2019). A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1559-1601. SID. https://sid.ir/paper/289174/en

Vancouver: Copy

ALANI NADEREH, Fazeli Sepideh. A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1559-1601. Available from: https://sid.ir/paper/289174/en

IEEE: Copy

NADEREH ALANI, and Sepideh Fazeli, “A Randomized Clinical Trial of Elemental Zinc Add-on Therapy on Clinical Outcomes of Patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1559–1601, 2019, [Online]. Available: https://sid.ir/paper/289174/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops