Novel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cells

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JAHANIAN NAJAFABADI ALI; MIRIAN MINA; ROHANI FATEMEH; KARAMI KAZEM; Hosseini Kharat Mahboubeh; SADEGHI ALIABADI HOJJAT

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1323-1331

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Title

Novel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cells

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Keywords

K562 cells

Cisplatin resistance

Palladacyclic complex

MTT assay

Apoptosis assay

Abstract

Today, development of resistance to anticancer drugs (including cisplatin) is noticed as a major problem. Recently several studies demonstrated that palladium complexes showed remarkable cytotoxic effects against K562 cell line and could be used efficiently for treatment of many human cancers including leukemia. Hereof, K562 cells were made resistant to cisplatin using increasing concentration of cisplatin up to 4. 5 mM and then cytotoxic effect of synthesized palladium complex was evaluated on this sub-line using MTT assay. Annexin V/ PI staining using flow cytometry and scanning electron microscopy (SEM) were performed to find out the mechanism of the observed cytotoxicity. Results indicated that tested compounds had a noticeable cytotoxic effect on K562 cells 80 times more than cisplatin. Palladium complex also showed significant cytotoxicity on resistant K562 sub-line. Flow cytometry and SEM results revealed that these compounds exert their cytotoxic effect via apoptosis and it could be concluded that the novel synthesized palladium complex might be a good candidate for replacing cisplatin in case of treatment of cisplatin resistant tumors.

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APA: Copy

JAHANIAN NAJAFABADI, ALI, MIRIAN, MINA, ROHANI, FATEMEH, KARAMI, KAZEM, Hosseini Kharat, Mahboubeh, & SADEGHI ALIABADI, HOJJAT. (2019). Novel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cells. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1323-1331. SID. https://sid.ir/paper/289176/en

Vancouver: Copy

JAHANIAN NAJAFABADI ALI, MIRIAN MINA, ROHANI FATEMEH, KARAMI KAZEM, Hosseini Kharat Mahboubeh, SADEGHI ALIABADI HOJJAT. Novel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cells. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1323-1331. Available from: https://sid.ir/paper/289176/en

IEEE: Copy

ALI JAHANIAN NAJAFABADI, MINA MIRIAN, FATEMEH ROHANI, KAZEM KARAMI, Mahboubeh Hosseini Kharat, and HOJJAT SADEGHI ALIABADI, “Novel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cells,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1323–1331, 2019, [Online]. Available: https://sid.ir/paper/289176/en

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