Synthesis and Biological Assessment of 2-Hydroxyiminoethanones as Anti-Inflammatory and β-Amyloid Aggregation Inhibitors

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VALIPOUR MEHDI; Davaji Issa; Abedi Niusha; RAJABI MAHSA; Kucukkilinc Tuba Tuylu; Ayazgok Beyza; IRANNEJAD HAMID

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1288-1298

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Title

Synthesis and Biological Assessment of 2-Hydroxyiminoethanones as Anti-Inflammatory and β-Amyloid Aggregation Inhibitors

Author(s)

Keywords

Synthesis

Anti-inflammatory

Alzheimer′

s disease

hydroxyiminoethanone

-amyloid aggregation

Abstract

Alzheimer’ s disease (AD) is a neuroinflammatory based pathologic state in which β;-amyloid aggregates are major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as Anti-inflammatory in carrageenan and formalin tests and inhibitors of β;-amyloid aggregation. Compounds 1-10b were synthesized through a twostep reaction. Results: Compounds 1-5b showed more β;-amyloid disaggregation ability than reference drugs rifampicin and donepezil and compound 2b was the best compound in this series and could reduce the extent of amyloid aggregation to 50. 9%. Interestingly, compounds 1b and 3b showed significant Anti-inflammatory activity in carrageenan-induced paw edema compared to control group and equivalent to the reference drug indomethacin. 2-Hydeoxyiminoethanones are privileged scaffold for further drug research and development as anti-neuroinflammatory and neuroprotective agents.

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APA: Copy

VALIPOUR, MEHDI, Davaji, Issa, Abedi, Niusha, RAJABI, MAHSA, Kucukkilinc, Tuba Tuylu, Ayazgok, Beyza, & IRANNEJAD, HAMID. (2019). Synthesis and Biological Assessment of 2-Hydroxyiminoethanones as Anti-Inflammatory and β-Amyloid Aggregation Inhibitors. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1288-1298. SID. https://sid.ir/paper/289181/en

Vancouver: Copy

VALIPOUR MEHDI, Davaji Issa, Abedi Niusha, RAJABI MAHSA, Kucukkilinc Tuba Tuylu, Ayazgok Beyza, IRANNEJAD HAMID. Synthesis and Biological Assessment of 2-Hydroxyiminoethanones as Anti-Inflammatory and β-Amyloid Aggregation Inhibitors. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1288-1298. Available from: https://sid.ir/paper/289181/en

IEEE: Copy

MEHDI VALIPOUR, Issa Davaji, Niusha Abedi, MAHSA RAJABI, Tuba Tuylu Kucukkilinc, Beyza Ayazgok, and HAMID IRANNEJAD, “Synthesis and Biological Assessment of 2-Hydroxyiminoethanones as Anti-Inflammatory and β-Amyloid Aggregation Inhibitors,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1288–1298, 2019, [Online]. Available: https://sid.ir/paper/289181/en

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