Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents

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BAHARLOUI MARYAM; Mirshokraee Sayed Ahmad; Monfared Aazam; HOUSHDAR TEHRANI MOHAMMAD HASSAN

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:3 Page(s): 1299-1308

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Title

Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents

Author(s)

BAHARLOUI MARYAM | Mirshokraee Sayed Ahmad | Monfared Aazam | HOUSHDAR TEHRANI MOHAMMAD HASSAN | Issue Writer Certificate

Keywords

Click chemistry

Triazole rings

Peptide analogues

Cancer

MTT assay

Abstract

Cancer disease is a great concern in the worldwide public health and current treatments do not give satisfactory results, so, developing novel therapeutic agents to combat Cancer is highly demanded. Nowadays, antiCancer peptides (ACPs) are becoming promising antiCancer drug candidates. This is due to several advantages inherited in peptide molecules, such as being usually with small size, high activity, low immunogenicity, good biocompatibility, diversity of sequence, and more modification sites for functionalization. To get benefit of these merits, in this work, we synthesized a new series of triazole-based analogues with peptide scaffold by employing Click chemistry and evaluated their antiCancer activities against breast, colon Cancer cell lines as well as fibroblast cells using MTT assay. Our results suggest that peptide scaffolds containing 1H-1, 2, 3-triazole ring group are toxic against colon and breast Cancer cells viability, and this effect was more pronounced on MDA-MB-231 cells compared with MCF-7 breast cells. As a conclusion, these designed Peptide analogues may be good and safe candidates as future antiCancer agents.

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APA: Copy

BAHARLOUI, MARYAM, Mirshokraee, Sayed Ahmad, Monfared, Aazam, & HOUSHDAR TEHRANI, MOHAMMAD HASSAN. (2019). Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1299-1308. SID. https://sid.ir/paper/289182/en

Vancouver: Copy

BAHARLOUI MARYAM, Mirshokraee Sayed Ahmad, Monfared Aazam, HOUSHDAR TEHRANI MOHAMMAD HASSAN. Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1299-1308. Available from: https://sid.ir/paper/289182/en

IEEE: Copy

MARYAM BAHARLOUI, Sayed Ahmad Mirshokraee, Aazam Monfared, and MOHAMMAD HASSAN HOUSHDAR TEHRANI, “Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1299–1308, 2019, [Online]. Available: https://sid.ir/paper/289182/en

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