Calixapap: Calixarene-based Cluster of Acetaminophen as a Novel Antiradical Agent

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Delnavaz Shahr Amirali; Nasuhi Pur Fazel; AKBARI DILMAGHANI KARIM

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Information Journal Paper

Title

Calixapap: Calixarene-based Cluster of Acetaminophen as a Novel Antiradical Agent

Author(s)

Delnavaz Shahr Amirali | Nasuhi Pur Fazel | AKBARI DILMAGHANI KARIM | Issue Writer Certificate

Keywords

Acetaminophen

Paracetamol

Calixarene

Cluster

Antiradical

Radical scavenger

Abstract

In this paper, the synthesis and free-radical scavenging capacity of novel calix[4]arenebased Cluster of Paracetamol was reported. The phenolic structures of Acetaminophen and calix[4]arene prompted us for designing a synthetic route for calix[4]arene-based cyclic tetramer of Paracetamol. The present chalice-shaped Cluster is the first example of Calixarene/ Acetaminophen hybrid and Paracetamol can be considered as ¼ of the synthetic cyclic tetramer. Free-radical scavenging tests were determined by the 2, 2-diphenyl-1-picrylhydrazyl radical in methanol. The results of Antiradical-testing showed the enhanced free-radical scavenging capacity (~ 10-fold) for the prepared chaliced-shaped Cluster with respect to the corresponding single therapeutic drug unit (Acetaminophen). It is maybe attributed to the multivalency, spatial preorganization, and synergistic effect of four impacted drug units in the Cluster structure (Clustering effect).

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APA: Copy

Delnavaz Shahr, Amirali, Nasuhi Pur, Fazel, & AKBARI DILMAGHANI, KARIM. (2019). Calixapap: Calixarene-based Cluster of Acetaminophen as a Novel Antiradical Agent. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 30-33. SID. https://sid.ir/paper/289186/en

Vancouver: Copy

Delnavaz Shahr Amirali, Nasuhi Pur Fazel, AKBARI DILMAGHANI KARIM. Calixapap: Calixarene-based Cluster of Acetaminophen as a Novel Antiradical Agent. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):30-33. Available from: https://sid.ir/paper/289186/en

IEEE: Copy

Amirali Delnavaz Shahr, Fazel Nasuhi Pur, and KARIM AKBARI DILMAGHANI, “Calixapap: Calixarene-based Cluster of Acetaminophen as a Novel Antiradical Agent,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 30–33, 2019, [Online]. Available: https://sid.ir/paper/289186/en

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