Docetaxel-Loaded Mixed Micelles and Polymersomes Composed of Poly (caprolactone)-Poly (ethylene glycol) (PEG-PCL) and Poly (lactic acid)-Poly (ethylene glycol) (PEG-PLA): Preparation and In-vitro Characterization

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KHODAVERDI ELHAM; TAYARANI NAJARAN ZAHRA; ALIBOLANDI MONA; HOSSEINI JAVAD; SEPAHI SAMANEH; KAMALI HOSSEIN; HADIZADEH FARZIN

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 142-155

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Title

Docetaxel-Loaded Mixed Micelles and Polymersomes Composed of Poly (caprolactone)-Poly (ethylene glycol) (PEG-PCL) and Poly (lactic acid)-Poly (ethylene glycol) (PEG-PLA): Preparation and In-vitro Characterization

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Keywords

Micelles

Polymersomes

Di-block copolymer

Docetaxel

C ytotoxicity

Abstract

Microwave irradiation was used to synthesize poly (caprolactone)-poly (ethylene glycol) (PEG-PCL) and poly (lactic acid)-poly (ethylene glycol) (PEG-PLA) copolymers that are composed of biodegradable polymers including PEG, PLA, and PCL. These copolymers were used for loading Docetaxel in nanoparticles. Single emulsion-solvent evaporation technique was applied for preparing the PEG-PLA and PEG-PCL mixed nanoparticles (Micelles and Polymersomes) with different proportions, including 0: 1, 1: 1, 3: 1, 1: 3, and 1: 0. The unimodal gel permeation chromatography curve showed low polydispersity of the Di-block copolymers. The in-vitro drug release curves of formulations were compared. Micelles and Polymersomes of 75% PEG-PCL and 25% PEG-PLA (P5 and M5) have the lowest burst release (5%) at the same period compared to the other copolymers. The dynamic light scattering and TEM results clarified that the size and shape of the formulations are uniform. The cytotoxicity effect of P5 and M5 was evaluated in different cell lines. The best one was found to P5 with half maximal inhibitory concentration (IC50) between 1. 48-11. 79 μ g/mL. The pro-apoptotic effect of P5 was confirmed with flow cytometry study. These mixed Micelles (M5) and Polymersomes (P5) was found to be superior formulations than non-mixed ones.

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APA: Copy

KHODAVERDI, ELHAM, TAYARANI NAJARAN, ZAHRA, ALIBOLANDI, MONA, HOSSEINI, JAVAD, SEPAHI, SAMANEH, KAMALI, HOSSEIN, & HADIZADEH, FARZIN. (2019). Docetaxel-Loaded Mixed Micelles and Polymersomes Composed of Poly (caprolactone)-Poly (ethylene glycol) (PEG-PCL) and Poly (lactic acid)-Poly (ethylene glycol) (PEG-PLA): Preparation and In-vitro Characterization. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 142-155. SID. https://sid.ir/paper/289187/en

Vancouver: Copy

KHODAVERDI ELHAM, TAYARANI NAJARAN ZAHRA, ALIBOLANDI MONA, HOSSEINI JAVAD, SEPAHI SAMANEH, KAMALI HOSSEIN, HADIZADEH FARZIN. Docetaxel-Loaded Mixed Micelles and Polymersomes Composed of Poly (caprolactone)-Poly (ethylene glycol) (PEG-PCL) and Poly (lactic acid)-Poly (ethylene glycol) (PEG-PLA): Preparation and In-vitro Characterization. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):142-155. Available from: https://sid.ir/paper/289187/en

IEEE: Copy

ELHAM KHODAVERDI, ZAHRA TAYARANI NAJARAN, MONA ALIBOLANDI, JAVAD HOSSEINI, SAMANEH SEPAHI, HOSSEIN KAMALI, and FARZIN HADIZADEH, “Docetaxel-Loaded Mixed Micelles and Polymersomes Composed of Poly (caprolactone)-Poly (ethylene glycol) (PEG-PCL) and Poly (lactic acid)-Poly (ethylene glycol) (PEG-PLA): Preparation and In-vitro Characterization,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 142–155, 2019, [Online]. Available: https://sid.ir/paper/289187/en

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