New Diterpenoids from the Aerial Parts of Salvia reuterana

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Moridi Farimani Mahdi; Miran Mansour; NEJAD EBRAHIMI SAMAD

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 406-411

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Title

New Diterpenoids from the Aerial Parts of Salvia reuterana

Author(s)

Moridi Farimani Mahdi | Miran Mansour | NEJAD EBRAHIMI SAMAD | Issue Writer Certificate

Keywords

Salvia reuterana

Labdane diterpene

Structure elucidation

NMR

Cytotoxicity

Abstract

The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new Labdane diterpene, 6β , 14α-dihydroxy-15-acetoxysclareol (1), and 14α , 15-dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly by 1D and 2D NMR spectroscopic techniques, including 1H-1H COSY, HSQC and HMBC methods and HR-ESI-TOFMS spectral data. Compound 1 and 2 were tested for their inhibitory activity toward HeLa and MCF-7 cell lines. Our results showed that S. reuterana is a rich source of labdane diterpenoids. These compounds are rather rare in Salvia species, although they are frequently found in other genera of the Lamiaceae. S. reuterana is a new source of these diterpenoids.

Cites

Short communication: Anti-Anxiety Effect of Salvia hypoleuca

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APA: Copy

Moridi Farimani, Mahdi, Miran, Mansour, & NEJAD EBRAHIMI, SAMAD. (2019). New Diterpenoids from the Aerial Parts of Salvia reuterana. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 406-411. SID. https://sid.ir/paper/289202/en

Vancouver: Copy

Moridi Farimani Mahdi, Miran Mansour, NEJAD EBRAHIMI SAMAD. New Diterpenoids from the Aerial Parts of Salvia reuterana. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):406-411. Available from: https://sid.ir/paper/289202/en

IEEE: Copy

Mahdi Moridi Farimani, Mansour Miran, and SAMAD NEJAD EBRAHIMI, “New Diterpenoids from the Aerial Parts of Salvia reuterana,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 406–411, 2019, [Online]. Available: https://sid.ir/paper/289202/en

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