A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer

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Bangaleh Zahra; BAGHERI SADEGHI HAYEDEH; EBRAHIMI SOLTAN AHMAD; NAJAFIZADEH PARVANEH

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 61-71

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Title

A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer

Author(s)

Bangaleh Zahra | BAGHERI SADEGHI HAYEDEH | EBRAHIMI SOLTAN AHMAD | NAJAFIZADEH PARVANEH | Issue Writer Certificate

Keywords

Phenylalanine

Potentiometric sensor

Molecular electrochemistry

MIPs

Abstract

Methods routinely utilized for detection of Phenylalanine in new-born blood consist of enzymatic assays, lacking sensitivity and HPLC assays which are expensive and timeconsuming to conduct. We, here, report for the first time, the construction of a Phenylalanine sensitive electrode, on the basis of a selective molecularly imprinted polymer, offering sensitivity, economy and ease of use for the measurement of Phenylalanine. The sensor was constructed of a graphite-rod electrode which was coated by MIP embedded polymer base made from polyvinyl chloride and plasticizer mixture, dissolved in THF. At optimized conditions the electrode revealed a Nernstian response 29. 73 ± 1. 0 mV decade-1 in a concentration range of 1 × 10⁻ ⁸ to 1 × 10-4 M with detection limit of 5 × 10⁻ ⁹ M. The potential response of the electrode was constant in the pH range of 4. 0– 7. 5. The electrode unfolded a response time of ~20 sec. The selectivity coefficient of the sensor towards a number of different amino acids with molecular similarities and some metal ions was evaluated. The sensor was successfully used for determination of Phenylalanine in blood serum and the results were in good compatibility with HPLC method.

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APA: Copy

Bangaleh, Zahra, BAGHERI SADEGHI, HAYEDEH, EBRAHIMI, SOLTAN AHMAD, & NAJAFIZADEH, PARVANEH. (2019). A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 61-71. SID. https://sid.ir/paper/289214/en

Vancouver: Copy

Bangaleh Zahra, BAGHERI SADEGHI HAYEDEH, EBRAHIMI SOLTAN AHMAD, NAJAFIZADEH PARVANEH. A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):61-71. Available from: https://sid.ir/paper/289214/en

IEEE: Copy

Zahra Bangaleh, HAYEDEH BAGHERI SADEGHI, SOLTAN AHMAD EBRAHIMI, and PARVANEH NAJAFIZADEH, “A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 61–71, 2019, [Online]. Available: https://sid.ir/paper/289214/en

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