The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAGHAVI FARZANEH SADAT; Namvar Parastoo; Sadeghzadeh Fatemeh; HAGHPARAST ABBAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 328-338

Download Full-Text

View:

169

Download:

182

Cites:

Information Journal Paper

Title

The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area

Author(s)

NAGHAVI FARZANEH SADAT | Namvar Parastoo | Sadeghzadeh Fatemeh | HAGHPARAST ABBAS | Issue Writer Certificate

Keywords

Reward

Dopaminergic system

Orexin

Hippocampus

Ventral tegmental area

Rat

Abstract

The activity of dopamine (DA)-containing neurons in the Ventral tegmental area (VTA) is a key mechanism in mesolimbic Reward processing that has modulatory effects on different diencephalic structures like Hippocampus (HIP), and receives inhibitory feedback and excitatory feed forward control. In addition, within the Hippocampus, DA receptors are mostly located in the dorsal part (CA1) and dopaminergic innervations are predominant in this sub-region. The current study aimed to examine the effect of intra-hippocampal CA1 administRation of SCH23390 and Sulpiride as D1-and D2-like receptor antagonists on the acquisition of Orexin-induced conditioned place preference (CPP), respectively. Cannulas were unilaterally implanted into the VTA and HIP of adult male albino Wistar Rats weighing 200-250 g. For induction of CPP, Orexin A (10 ng/0. 3 μ L saline) was daily microinjected into the VTA during a three-day conditioning phase. Thereafter, various doses of SCH23390 and Sulpiride (0. 25, 1 and 4 μ g) were unilaterally injected into the CA1 during this 3-day conditioning phase after intra-VTA administRation. The conditioning score was then calculated. Results revealed that intra-CA1 administRation of D1-and D2-like receptor antagonists during the 3-day conditioning phase attenuated the acquisition of place preference by Orexin A in a dosedependent manner. It seems the effect of D2-like receptor antagonist within the CA1 region of Hippocampus on this phenomenon was found to be more considerable than that of D1-like receptor antagonist. It is concluded that Orexin-induced CPP may be mediated, at least in part, by stimulation of DA receptors in the CA1.

Cites

No record.

References

No record.

Cite

APA: Copy

NAGHAVI, FARZANEH SADAT, Namvar, Parastoo, Sadeghzadeh, Fatemeh, & HAGHPARAST, ABBAS. (2019). The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 328-338. SID. https://sid.ir/paper/289218/en

Vancouver: Copy

NAGHAVI FARZANEH SADAT, Namvar Parastoo, Sadeghzadeh Fatemeh, HAGHPARAST ABBAS. The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):328-338. Available from: https://sid.ir/paper/289218/en

IEEE: Copy

FARZANEH SADAT NAGHAVI, Parastoo Namvar, Fatemeh Sadeghzadeh, and ABBAS HAGHPARAST, “The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 328–338, 2019, [Online]. Available: https://sid.ir/paper/289218/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops