Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways

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SEIFABADI SIMA; VASEGHI GOLNAZ; GHANNADIAN MUSTAFA; HAGHJOOY JAVANMARD SHAGHAYEGH

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:1 Page(s): 348-357

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Title

Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways

Author(s)

SEIFABADI SIMA | VASEGHI GOLNAZ | GHANNADIAN MUSTAFA | HAGHJOOY JAVANMARD SHAGHAYEGH | Issue Writer Certificate

Keywords

Pomegranate Pericarp

Tumor Growth

Vascular Endothelial Growth Factor

Tumor Proliferation

Angiogenesis

Abstract

Melanoma is a challenging disease to treat. Punica granatum L. has a potential anticancer effect. This study determined the antiproliferative and antiangiogenic potential of the extract from Pomegranate Pericarp (PPE) in melanoma. Melanoma cells (1 × 106) were injected to C57BL6 mice subcutaneously. On 8th day, mice were randomly divided into 9 groups. Group 1 was considered as control and received distilled water. Groups 2 to 5 received 50, 100, 200 or 400 mg/kg of standardized PPE, orally. Group 6 received 400 mg/kg PPE and PPAR-γ antagonist (T0070907, 5 mg/kg/day). Group 7 received 400 mg/kg PPE and PPAR-α antagonist (GW6471, 10 mg/kg/day). Groups 8 and 9 received PPAR antagonists alone. On the 16th day, mice were euthanized and the tumor samples were analyzed by immunohistochemistry staining for Ki-67 and CD31. Vascular Endothelial Growth Factor (VEGF) plasma level was determined by ELISA. PPE at the doses of 50, 100, 200, and 400 mg/kg decreased tumor weight to 1. 28, 1. 03, 0. 82, and 0. 58 g, respectively, in comparison with 1. 46 g in control group. Tumor volume reduced to 2. 1, 1. 7, 1. 35 and 0. 95 cm3 at the mentioned doses, in comparison with 2. 4 cm3 in control group (P < 0. 05 for all groups). VEGF, Ki-67 and CD31 were decreased dose dependently in the treatment groups (P < 0. 05). PPARα and PPARγ antagonists significantly reduced the extract effects (P < 0. 05). It was concluded that PPE may have a potential implication in melanoma treatment through activation of PPARα and PPARγ receptors.

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APA: Copy

SEIFABADI, SIMA, VASEGHI, GOLNAZ, GHANNADIAN, MUSTAFA, & HAGHJOOY JAVANMARD, SHAGHAYEGH. (2019). Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 348-357. SID. https://sid.ir/paper/289219/en

Vancouver: Copy

SEIFABADI SIMA, VASEGHI GOLNAZ, GHANNADIAN MUSTAFA, HAGHJOOY JAVANMARD SHAGHAYEGH. Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):348-357. Available from: https://sid.ir/paper/289219/en

IEEE: Copy

SIMA SEIFABADI, GOLNAZ VASEGHI, MUSTAFA GHANNADIAN, and SHAGHAYEGH HAGHJOOY JAVANMARD, “Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 348–357, 2019, [Online]. Available: https://sid.ir/paper/289219/en

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