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Information Journal Paper

Title

Oliveria decumbens, a Bioactive Essential Oil: Chemical Composition and Biological Activities

Pages

  412-421

Abstract

 Oliveria decumbens is an aromatic plant traditionally used for treatment of infections and gastrointestinal diseases. In the present study, the volatile oil of the plant was obtained by hydrodistillation and analyzed by GC-MS. In addition, Antibacterial and Anti-Helicobacter pylori activities of this essential oil were determined using disc diffusion and agar dilution methods, respectively. Insecticidal activity was assessed through topical and fumigation application of the essential oil to cabbage looper larvae. Acetylcholinesterase (AChE) inhibition by the essential oil was examined using Ellman’ s method. Furthermore, its Cytotoxic potential against three different cancer cell lines was assessed using the MTT assay. The phenolic monoterpenoids, thymol (38. 79%), and carvacrol (36. 30%) were identified as major constituents of the essential oil. We observed significant Antibacterial activity of the essential oil against H. pylori (MIC=20. 4 μ g /mL) as well as other tested bacteria, except for Pseudomonas aeruginosa. O. decumbens essential oil showed significant toxicity to cabbage looper larvae with LD50 value of 52. 1 μ g /larva following topical and fumigant administration. O. decumbens essential oil was considerably inhibitory to Acetylcholinesterase activity (IC50 = 0. 117 μ g/mL). Cytotoxic assay of the volatile oil resulted in IC50 = 0. 065, 0. 104, and 0. 141 μ g/mL for MCF-7, T47D and MDA-MB-231 cell lines, respectively. According to our data, this species with high concentrations of thymol and carvacrol could be considered as a natural source for pharmaceutical products.

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    APA: Copy

    Eftekhari, Mahdieh, SHAMS ARDEKANI, MOHAMMAD REZA, AMIN, MOHSEN, ATTAR, FARIDEH, AKBARZADEH, TAHMINEH, SAFAVI, MALIHEH, ELAHE KARIMPOUR RAZKENARI, ELAHE, AMINI, MOHSEN, Isman, Murray, & KHANAVI, MAHNAZ. (2019). Oliveria decumbens, a Bioactive Essential Oil: Chemical Composition and Biological Activities. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(1), 412-421. SID. https://sid.ir/paper/289220/en

    Vancouver: Copy

    Eftekhari Mahdieh, SHAMS ARDEKANI MOHAMMAD REZA, AMIN MOHSEN, ATTAR FARIDEH, AKBARZADEH TAHMINEH, SAFAVI MALIHEH, ELAHE KARIMPOUR RAZKENARI ELAHE, AMINI MOHSEN, Isman Murray, KHANAVI MAHNAZ. Oliveria decumbens, a Bioactive Essential Oil: Chemical Composition and Biological Activities. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(1):412-421. Available from: https://sid.ir/paper/289220/en

    IEEE: Copy

    Mahdieh Eftekhari, MOHAMMAD REZA SHAMS ARDEKANI, MOHSEN AMIN, FARIDEH ATTAR, TAHMINEH AKBARZADEH, MALIHEH SAFAVI, ELAHE ELAHE KARIMPOUR RAZKENARI, MOHSEN AMINI, Murray Isman, and MAHNAZ KHANAVI, “Oliveria decumbens, a Bioactive Essential Oil: Chemical Composition and Biological Activities,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 1, pp. 412–421, 2019, [Online]. Available: https://sid.ir/paper/289220/en

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