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Information Journal Paper

Title

INCREASED URINARY NEOPTERIN: CREATININE RATIO AS A MARKER OF ACTIVATION OF CELL-MEDIATED IMMUNITY AND OXIDATIVE STRESS IN THE IRANIAN PATIENTS WITH MULTIPLE SCLEROSIS

Pages

  155-158

Abstract

 Neopterin, a pyrazinopyrimidine compound, is produced by macrophages after induction by interferon gamma (IFN-g) and serves as a marker of cellular immune system activation followed by oxidative stress. The aim of this study was to determine urinary NEOPTERIN to creatinine ratio (UNCR) as a surrogate marker of cell-mediated immune activation in MULTIPLE SCLEROSIS (MS). Three weekly early morning urine samples were collected from 27 patients with MS and 31 age- and sex-matched apparently healthy subjects. Urinary NEOPTERIN and creatinine were determined using reversed phase high-performance liquid chromatography and Jaffe reaction, respectively. UNCR was significantly higher in patients than in healthy controls indicating IFN-g-induced cellular immunity activation and oxidative stress in MULTIPLE SCLEROSIS. As a non-invasive method, UNCR determination may be helpful in monitoring disease progression and the effects of therapies, as well.

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    APA: Copy

    KHORAMI, H., NEYESTANI, T.R., KADKHODAEI, M., & LOTFI, J.. (2003). INCREASED URINARY NEOPTERIN: CREATININE RATIO AS A MARKER OF ACTIVATION OF CELL-MEDIATED IMMUNITY AND OXIDATIVE STRESS IN THE IRANIAN PATIENTS WITH MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 2(3), 155-158. SID. https://sid.ir/paper/291028/en

    Vancouver: Copy

    KHORAMI H., NEYESTANI T.R., KADKHODAEI M., LOTFI J.. INCREASED URINARY NEOPTERIN: CREATININE RATIO AS A MARKER OF ACTIVATION OF CELL-MEDIATED IMMUNITY AND OXIDATIVE STRESS IN THE IRANIAN PATIENTS WITH MULTIPLE SCLEROSIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2003;2(3):155-158. Available from: https://sid.ir/paper/291028/en

    IEEE: Copy

    H. KHORAMI, T.R. NEYESTANI, M. KADKHODAEI, and J. LOTFI, “INCREASED URINARY NEOPTERIN: CREATININE RATIO AS A MARKER OF ACTIVATION OF CELL-MEDIATED IMMUNITY AND OXIDATIVE STRESS IN THE IRANIAN PATIENTS WITH MULTIPLE SCLEROSIS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 2, no. 3, pp. 155–158, 2003, [Online]. Available: https://sid.ir/paper/291028/en

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