P-GLYCOPROTEIN QUANTITATION IN ACUTE LEUKEMIA

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NIKOU GOFTAR M.; FARHADI M.; POURFATH ELAH A.A.

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2003 | Volume:2 | Issue:2 Page(s): 57-60

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Title

P-GLYCOPROTEIN QUANTITATION IN ACUTE LEUKEMIA

Author(s)

NIKOU GOFTAR M. | FARHADI M. | POURFATH ELAH A.A. | Issue Writer Certificate

Keywords

LEUKEMIA

DRUG RESISTANCE

P-GLYCOPROTEIN

FLOWCYTOMETRY

FAB CLASSIFICATION

IMMUNOPHENOTYPING

MEAN FLUORESCENCE INTENSITY

Abstract

Multi DRUG RESISTANCE(MDR) is a major problem in the treatment of cancer and hematological malignancies. This resistance is multi factorial and is the result of decreased intra cellular drug accumulation. This is partly due to the presence of a 170KD intra membranous protein termed P-GLYCOPROTEIN(p-gp) that is an energydependent efflux pump which has increased expression on drug-resistance cells. In this study we identified the presence ofP-gp by staining with Fluorescent Iso Thio Cyanate (FITC) conjugated anti P-gp in acute LEUKEMIA patients and flow cytometry in addition to performing immunophenotype analysis and French, American British (FAB) classification. Results revealed that one fifth of leukemic patients exp~essed P-gp and this phenotype was more prevalent in Acute Undifferentiated LEUKEMIA(AUL) and Acute Myelogenous LEUKEMIA (AML) than in Acute Lymphoblastic LEUKEMIA(ALL). Other findings showed a logical relationship between this phenotype and age groups. There was not any association between P-gp+ phenotype and FAB and IMMUNOPHENOTYPING sub classification, but there was a linear relationship between CD34 and CD7 expression and P-gp+ phenotype. The accumulation ofP-gp molecule that was stated as Mean Fluorescence Intensity (MFI) on the blasts membrane ofAUL and AML patients showed marked increase in comparison to ALL. Furthermore MFI in P-gp+ relapsed patients was much more than P-gp+ pretreatment patients.

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APA: Copy

NIKOU GOFTAR, M., FARHADI, M., & POURFATH ELAH, A.A.. (2003). P-GLYCOPROTEIN QUANTITATION IN ACUTE LEUKEMIA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 2(2), 57-60. SID. https://sid.ir/paper/291068/en

Vancouver: Copy

NIKOU GOFTAR M., FARHADI M., POURFATH ELAH A.A.. P-GLYCOPROTEIN QUANTITATION IN ACUTE LEUKEMIA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2003;2(2):57-60. Available from: https://sid.ir/paper/291068/en

IEEE: Copy

M. NIKOU GOFTAR, M. FARHADI, and A.A. POURFATH ELAH, “P-GLYCOPROTEIN QUANTITATION IN ACUTE LEUKEMIA,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 2, no. 2, pp. 57–60, 2003, [Online]. Available: https://sid.ir/paper/291068/en

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