NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED
MACROPHAGES

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YARAEE ROYA; EBTEKAR M.; AHMADIANI A.; SABAHI F.

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2003 | Volume:2 | Issue:2 Page(s): 95-100

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Title

NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES

Author(s)

YARAEE ROYA | EBTEKAR M. | AHMADIANI A. | SABAHI F. | Issue Writer Certificate

Keywords

SUBSTANCE P

CALCITONIN GENE-RELATED PEPTIDE

MACROPHAGE

HERPES SIMPLEX VIMS TYPE -1

INTERLEUKIN-1 BETA.

Abstract

Neuropeptides, possessing specific and functional receptors on various cells of the immune system, have the potential to regulate immune responses; and the macrophages as important components of defense against various agents, are at their influence. In this study the effect of neuropeptides SUBSTANCE P (SP) and calcitonin gene-related peptide (CGRP) on IL-1 beta production by herpes simplex type-l (HSV-1)-infected and also uninfected mouse peritoneal MACROPHAGEs were considered. Each neuropeptide separately has upregulated IL-1 beta production by HSV-1 infected MACROPHAGEs with the greatest effect at the concentrations of 10-9 M for both SP and CGRP, but no synergistic effect on IL-1 production has been observed in the presence of both neuropeptides at optimal concentrations. IL-1β production by uninfected MACROPHAGEs was also moderately enhanced in the presence of each neuropeptide, but not in the presence of both neuropeptides simultaneously. It can be concluded that IL-1β production, which is part of MACROPHAGE mediated inflammatory response to HSV-1, is enhanced by specific doses of neuropeptides.

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APA: Copy

YARAEE, ROYA, EBTEKAR, M., AHMADIANI, A., & SABAHI, F.. (2003). NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 2(2), 95-100. SID. https://sid.ir/paper/291076/en

Vancouver: Copy

YARAEE ROYA, EBTEKAR M., AHMADIANI A., SABAHI F.. NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2003;2(2):95-100. Available from: https://sid.ir/paper/291076/en

IEEE: Copy

ROYA YARAEE, M. EBTEKAR, A. AHMADIANI, and F. SABAHI, “NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 2, no. 2, pp. 95–100, 2003, [Online]. Available: https://sid.ir/paper/291076/en

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