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Information Journal Paper

Title

THE EFFECT OF VITAMIN E ON SPLENOCYTES APOPTOSIS OF GAMMA-IRRADIATED BALB/C MICE

Pages

  77-82

Abstract

 APOPTOSIS, a physiologic mechanism to eliminate unwanted cells, is also induced by ionizing irradiation, through production of FREE RADICALS. It has been demonstrated that antioxidants such as VITAMIN E are able to protect cells from damage caused by FREE RADICALS. Taken together we found it reasonable to make an attempt to evaluate the protective effect of VITAMIN E against APOPTOSIS. The irradiated mice received 1 Gy/day GAMMA RADIATION for one day (low dose) or for three successive days (high dose, 3Gy). The splenocytes were then isolated at 6, 14 and 24 h after exposure. DNA gel electrophoresis and DNA fragmentation assay were done in addition to the evaluation of splenocytes cytology.Our results showed that VITAMIN E can reduce APOPTOSIS against low dose irradiation. However it is not able to completely block programmed cell death in high dose irradiation.

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    APA: Copy

    MAROUFI, B., KABOUDANIAN ARDESTANI, S., KARIMINIA, AMINA, & NADERIMANESH, H.. (2005). THE EFFECT OF VITAMIN E ON SPLENOCYTES APOPTOSIS OF GAMMA-IRRADIATED BALB/C MICE. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 4(2), 77-82. SID. https://sid.ir/paper/291093/en

    Vancouver: Copy

    MAROUFI B., KABOUDANIAN ARDESTANI S., KARIMINIA AMINA, NADERIMANESH H.. THE EFFECT OF VITAMIN E ON SPLENOCYTES APOPTOSIS OF GAMMA-IRRADIATED BALB/C MICE. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2005;4(2):77-82. Available from: https://sid.ir/paper/291093/en

    IEEE: Copy

    B. MAROUFI, S. KABOUDANIAN ARDESTANI, AMINA KARIMINIA, and H. NADERIMANESH, “THE EFFECT OF VITAMIN E ON SPLENOCYTES APOPTOSIS OF GAMMA-IRRADIATED BALB/C MICE,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 4, no. 2, pp. 77–82, 2005, [Online]. Available: https://sid.ir/paper/291093/en

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