ASSOCIATION BETWEEN THE POLYMORPHISM OF TGF-Β1 GENE PROMOTER (-509C>T) AND IDIOPATHIC CHRONIC URTICARIA

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TAVAKOL AFSHARI J.; HOSSEINI FARAHABADI S.; GANJALI R.; RAFATPANAH H.; FARID HOSSEINI R.; GHAFFARI J.

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Journal Paper

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2006 | Volume:5 | Issue:3 Page(s): 109-113

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Title

ASSOCIATION BETWEEN THE POLYMORPHISM OF TGF-Β1 GENE PROMOTER (-509C>T) AND IDIOPATHIC CHRONIC URTICARIA

Author(s)

Keywords

POLYMORPHISM

TGF-Β1 GENE

URTICARIA

Abstract

Idiopathic Chronic URTICARIA (ICU), the most common form (70-80%) of chronic URTICARIA is supposed to have immune basis causes. It is speculated that the promoter POLYMORPHISM of TGF-Β1 GENE may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-β1 promoter –509C>T POLYMORPHISM was determined by PCR-RFLP method. Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele. These results do suggest an influence of genetic variability at the promoter of TGF-Β1 GENE (-509C>T) on the occurrence of ICU. This POLYMORPHISM has been shown as a useful genetic change in our study. Further work is required to confirm this result.

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APA: Copy

TAVAKOL AFSHARI, J., HOSSEINI FARAHABADI, S., GANJALI, R., RAFATPANAH, H., FARID HOSSEINI, R., & GHAFFARI, J.. (2006). ASSOCIATION BETWEEN THE POLYMORPHISM OF TGF-Β1 GENE PROMOTER (-509C>T) AND IDIOPATHIC CHRONIC URTICARIA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 5(3), 109-113. SID. https://sid.ir/paper/291126/en

Vancouver: Copy

TAVAKOL AFSHARI J., HOSSEINI FARAHABADI S., GANJALI R., RAFATPANAH H., FARID HOSSEINI R., GHAFFARI J.. ASSOCIATION BETWEEN THE POLYMORPHISM OF TGF-Β1 GENE PROMOTER (-509C>T) AND IDIOPATHIC CHRONIC URTICARIA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2006;5(3):109-113. Available from: https://sid.ir/paper/291126/en

IEEE: Copy

J. TAVAKOL AFSHARI, S. HOSSEINI FARAHABADI, R. GANJALI, H. RAFATPANAH, R. FARID HOSSEINI, and J. GHAFFARI, “ASSOCIATION BETWEEN THE POLYMORPHISM OF TGF-Β1 GENE PROMOTER (-509C>T) AND IDIOPATHIC CHRONIC URTICARIA,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 5, no. 3, pp. 109–113, 2006, [Online]. Available: https://sid.ir/paper/291126/en

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