EXPRESSION OF IL-17 AND COX2 GENE IN PERIPHERAL BLOOD LEUKOCYTES OF VITILIGO PATIENTS

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ESMAEILI BEHNAZ; REZAEE SEYED ABDOL RAHIM; LAYEGH POURAN; TAVAKKOL AFSHARI JALIL; DYE PHIL; GHAYOOR KARIMIANI EHSAN; KALALINIA FATEMEH; RAFATPANAH HOUSHANG

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2011 | Volume:10 | Issue:2 Page(s): 81-89

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Title

EXPRESSION OF IL-17 AND COX2 GENE IN PERIPHERAL BLOOD LEUKOCYTES OF VITILIGO PATIENTS

Author(s)

Keywords

COX2

IL-17

NEUTROPHILS

REAL-TIME PCR

VITILIGO EXPRESSION OF IL-17 AND COX2 GENE IN PERIPHERAL BLOOD LEUKOCYTES OF VITILIGO PATIENTS

Abstract

Vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. Interleukin 17 (IL-17A) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (COX2). The aim of this study was to investigate the gene expression of IL-17 and COX2 in peripheral blood leukocytes of vitiligo's patients.Peripheral blood leukocytes from 15 patients with vitiligo and 15 healthy controls were separated using a gradient density centrifugation method. After total RNA isolation and cDNA synthesis, IL-17 and COX2 gene expression were quantified by real-time polymerase chain reaction (PCR).There were no significant differences in IL-17 and COX2 gene expression in lymphocytes of patients with vitiligo compared with control group (p <0.05). However there was an increased IL-17 and COX2 gene expression in NEUTROPHILS of patients compared to controls, but it did not reach statistical significance (p=0.05). We could not find any differences in IL-17 and COX2 gene expression between clinical diseases subtypes, sex and age. There was a significant correlation between IL-17 and COX2 genes expression in the NEUTROPHILS of patients (p=0.00, r=0.80).Our results showed an increased expression in IL-17 and Cox-2 genes in neurophils of patients with vitiligo. This suggested that these two factors are involved in the inflammatory process. Further studies with a larger sample size might help to establish the role of these factors in the pathogenesis of diseases.

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ASSOCIATION BETWEEN COX-2 A1195G POLYMORPHISM WITH MIGRAINE IN PATIENTS WITH CONSANGUINEOUS MARRIAGE OF PARENTS

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APA: Copy

ESMAEILI, BEHNAZ, REZAEE, SEYED ABDOL RAHIM, LAYEGH, POURAN, TAVAKKOL AFSHARI, JALIL, DYE, PHIL, GHAYOOR KARIMIANI, EHSAN, KALALINIA, FATEMEH, & RAFATPANAH, HOUSHANG. (2011). EXPRESSION OF IL-17 AND COX2 GENE IN PERIPHERAL BLOOD LEUKOCYTES OF VITILIGO PATIENTS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 10(2), 81-89. SID. https://sid.ir/paper/291280/en

Vancouver: Copy

ESMAEILI BEHNAZ, REZAEE SEYED ABDOL RAHIM, LAYEGH POURAN, TAVAKKOL AFSHARI JALIL, DYE PHIL, GHAYOOR KARIMIANI EHSAN, KALALINIA FATEMEH, RAFATPANAH HOUSHANG. EXPRESSION OF IL-17 AND COX2 GENE IN PERIPHERAL BLOOD LEUKOCYTES OF VITILIGO PATIENTS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2011;10(2):81-89. Available from: https://sid.ir/paper/291280/en

IEEE: Copy

BEHNAZ ESMAEILI, SEYED ABDOL RAHIM REZAEE, POURAN LAYEGH, JALIL TAVAKKOL AFSHARI, PHIL DYE, EHSAN GHAYOOR KARIMIANI, FATEMEH KALALINIA, and HOUSHANG RAFATPANAH, “EXPRESSION OF IL-17 AND COX2 GENE IN PERIPHERAL BLOOD LEUKOCYTES OF VITILIGO PATIENTS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 10, no. 2, pp. 81–89, 2011, [Online]. Available: https://sid.ir/paper/291280/en

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