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Information Journal Paper

Title

MICB GENE EXPRESSION ON PERIPHERAL BLOOD MONONUCLEAR CELLS AND SUSCEPTIBILITY TO MULTIPLE SCLEROSIS IN NORTH OF IRAN

Pages

  261-265

Abstract

 Multiple sclerosis (MS) is an autoimmune multifactorial degenerative disease with detrimental affliction on central nervous system. MHC class I chain- related gene A, B (MICA and MICB) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation.The purpose of this study was to evaluate the MICA and MICB MRNA expression in MULTIPLE SCLEROSIS patients. In this study, we evaluated MICA and MICB MRNA expression in the pripheral blood mononuclear cells by reverse transcryptase-polymerase chain reaction (RT-PCR) in MS patients and normal controls.The results of this study showed that 32.6% of patients with progressive clinical outcome over expressed MICB genes in comparison with controls (p=0.002).It is concluded that the high expression of MICB gene in MS patients is an important criterion of MS disease that it may be due to the interaction between MICB and its receptor on CD8+T or NK cells.

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    APA: Copy

    ABEDIAN KENARI, SAEID, YOUSEFZADEH, YOUSEF, MAJIDI, MOHAMMAD, GHASEMI, MARYAM, NASEHI, MOHAMMAD MAHDI, GHAFFARI, JAVAD, HABIBI SARAVI, REZA, ABEDINI, MAHMOUD, & ELYASI, MITRA. (2011). MICB GENE EXPRESSION ON PERIPHERAL BLOOD MONONUCLEAR CELLS AND SUSCEPTIBILITY TO MULTIPLE SCLEROSIS IN NORTH OF IRAN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 10(4), 261-265. SID. https://sid.ir/paper/291334/en

    Vancouver: Copy

    ABEDIAN KENARI SAEID, YOUSEFZADEH YOUSEF, MAJIDI MOHAMMAD, GHASEMI MARYAM, NASEHI MOHAMMAD MAHDI, GHAFFARI JAVAD, HABIBI SARAVI REZA, ABEDINI MAHMOUD, ELYASI MITRA. MICB GENE EXPRESSION ON PERIPHERAL BLOOD MONONUCLEAR CELLS AND SUSCEPTIBILITY TO MULTIPLE SCLEROSIS IN NORTH OF IRAN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2011;10(4):261-265. Available from: https://sid.ir/paper/291334/en

    IEEE: Copy

    SAEID ABEDIAN KENARI, YOUSEF YOUSEFZADEH, MOHAMMAD MAJIDI, MARYAM GHASEMI, MOHAMMAD MAHDI NASEHI, JAVAD GHAFFARI, REZA HABIBI SARAVI, MAHMOUD ABEDINI, and MITRA ELYASI, “MICB GENE EXPRESSION ON PERIPHERAL BLOOD MONONUCLEAR CELLS AND SUSCEPTIBILITY TO MULTIPLE SCLEROSIS IN NORTH OF IRAN,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 10, no. 4, pp. 261–265, 2011, [Online]. Available: https://sid.ir/paper/291334/en

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