COMPARISON OF IMMUNOMODULATING PROPERTIES OF BETA-LACTOGLOBULIN AND ITS HYDROLYSATES

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DUAN CUI CUI; LI AI LI; YANG LI JIE; ZHAO RUI; FAN WEN GUANG; HUO GUI CHENG

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2014 | Volume:13 | Issue:1 Page(s): 26-32

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Title

COMPARISON OF IMMUNOMODULATING PROPERTIES OF BETA-LACTOGLOBULIN AND ITS HYDROLYSATES

Author(s)

Keywords

HYDROLYSIS

HYPERSENSITIVITY

LACTOGLOBULINS

MILK

Abstract

Cow's MILK allergy is one of the most common food allergies in childhood. Beta-lactoglobulin (b- Lg) is a dominant allergen in cow's MILK. HYDROLYSIS is known as an effective method to reduce the allergenicity of proteins. Thus, the objective of this study was to compare the allergenicity of b-Lg and its hydrolysates using an animal model.Twenty four BALB/c mice were divided into three groups and subcutaneously injected with native bovine b-Lg and its hydrolysates on days 0, 7 and 14. During the sensitization period, a number of systemic anaphylactic indicators were observed in mice sensitized by b-Lg compared to those sensitized by hydrolysates of b-Lg.Mice sensitized by hydrolysates of b-Lg showed a significantly lower spleen lymphocyte proliferation level than that sensitized by intact b-Lg. Antibody levels of b-Lg-specific IgE in serum induced by native b-Lg were significantly high. Plasma histamine levels were also evaluated and showed the same trend as IgE. Moreover, the hydrolysates of b-Lg significantly down-regulated IL-4 and IL-5 secretions in serum.These results suggested that enzymatic HYDROLYSIS could reduce the allergenicity of b-Lg.

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APA: Copy

DUAN, CUI CUI, LI, AI LI, YANG, LI JIE, ZHAO, RUI, HUO, GUI CHENG, & FAN, WEN GUANG. (2014). COMPARISON OF IMMUNOMODULATING PROPERTIES OF BETA-LACTOGLOBULIN AND ITS HYDROLYSATES. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(1), 26-32. SID. https://sid.ir/paper/291377/en

Vancouver: Copy

DUAN CUI CUI, LI AI LI, YANG LI JIE, ZHAO RUI, HUO GUI CHENG, FAN WEN GUANG. COMPARISON OF IMMUNOMODULATING PROPERTIES OF BETA-LACTOGLOBULIN AND ITS HYDROLYSATES. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(1):26-32. Available from: https://sid.ir/paper/291377/en

IEEE: Copy

CUI CUI DUAN, AI LI LI, LI JIE YANG, RUI ZHAO, GUI CHENG HUO, and WEN GUANG FAN, “COMPARISON OF IMMUNOMODULATING PROPERTIES OF BETA-LACTOGLOBULIN AND ITS HYDROLYSATES,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 1, pp. 26–32, 2014, [Online]. Available: https://sid.ir/paper/291377/en

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