LACK OF ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM RS10818488 IN TRAF1/C5 REGION AND RHEUMATOID ARTHRITIS IN IRANIAN POPULATION

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AHMADLOU SOMAYEH; AKHIANI MOHSEN; SALIMZADEH AHMAD; KERAMATIPOUR MOHAMMAD

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2014 | Volume:13 | Issue:1 Page(s): 19-25

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Title

LACK OF ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM RS10818488 IN TRAF1/C5 REGION AND RHEUMATOID ARTHRITIS IN IRANIAN POPULATION

Author(s)

AHMADLOU SOMAYEH | AKHIANI MOHSEN | SALIMZADEH AHMAD | KERAMATIPOUR MOHAMMAD | Issue Writer Certificate

Keywords

ASSOCIATION STUDY

RHEUMATOID ARTHRITIS

SINGLE NUCLEOTIDE POLYMORPHISM (SNP)

TRAF1

Abstract

The association of rs10818488 SNP located in TRAF1/C5 region with RHEUMATOID ARTHRITIS (RA), has been picked up by genome-wide association studies. Independent studies in different populations revealed inconsistent results. The aim of this study was to investigate the possible association of this SNP with RA in Iranian population.A total of 362 cases and 422 healthy controls were recruited in this study. Genomic DNA was extracted from whole blood and the genotyping was performed by PCR-RFLP (Polymerase Chain Reaction–Restriction Fragment Length Polymorphism). A set of genotypes was confirmed by sequencing. Genotype and allele frequencies were compared between the case and control groups.Analysis indicated a higher frequency of A allele in cases, although the difference was not statistically significant (Chi-square=2.8, p=0.09). Comparison of genotype frequencies, revealed higher frequencies of AA and AG genotypes in case group but statistically the difference was not significant (Chi-square=2.72, p=0.25).These findings suggest that the rs10818488 in TRAF1/C5 region is not associated with RHEUMATOID ARTHRITIS in Iranian population.

Cites

SINGLE NUCLEOTIDE POLYMORPHISM RS 2476601 OF PTPN22 GENE AND SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IN IRANIAN POPULATION

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APA: Copy

AHMADLOU, SOMAYEH, AKHIANI, MOHSEN, SALIMZADEH, AHMAD, & KERAMATIPOUR, MOHAMMAD. (2014). LACK OF ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM RS10818488 IN TRAF1/C5 REGION AND RHEUMATOID ARTHRITIS IN IRANIAN POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(1), 19-25. SID. https://sid.ir/paper/291378/en

Vancouver: Copy

AHMADLOU SOMAYEH, AKHIANI MOHSEN, SALIMZADEH AHMAD, KERAMATIPOUR MOHAMMAD. LACK OF ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM RS10818488 IN TRAF1/C5 REGION AND RHEUMATOID ARTHRITIS IN IRANIAN POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(1):19-25. Available from: https://sid.ir/paper/291378/en

IEEE: Copy

SOMAYEH AHMADLOU, MOHSEN AKHIANI, AHMAD SALIMZADEH, and MOHAMMAD KERAMATIPOUR, “LACK OF ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM RS10818488 IN TRAF1/C5 REGION AND RHEUMATOID ARTHRITIS IN IRANIAN POPULATION,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 1, pp. 19–25, 2014, [Online]. Available: https://sid.ir/paper/291378/en

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